Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이수재 | - |
dc.date.accessioned | 2016-11-17T06:55:47Z | - |
dc.date.available | 2016-11-17T06:55:47Z | - |
dc.date.issued | 2015-05 | - |
dc.identifier.citation | AQUATIC TOXICOLOGY, v. 165, Page. 136-143 | en_US |
dc.identifier.issn | 0166-445X | - |
dc.identifier.issn | 1879-1514 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S0166445X1500171X | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/24448 | - |
dc.description.abstract | 2,2',4,4'-tetrabromodiphenyl ether #BDE-47# and perfluorooctane sulfonate #PFOS# are widely dispersed persistent organic pollutants #POPs# in the marine ecosystem. However, their toxic effects on marine organisms are still poorly understood. In this study, we investigated the effects of BDE-47 and PFOS on development and reproduction at the organismal level and reactive oxygen species #ROS# production and gene expression patterns of the defensome at the cellular level in the intertidal copepod Tigriopus japonicus. In copepods exposed to BDE-47 and PFOS, we observed developmental retardation and reduced fecundity, suggesting repercussions on in vivo endpoints through alterations to the normal molting and reproduction system of T. japonicus. BDE-47 and PFOS increased levels of ROS in T. japonicus in a concentration-dependent manner, indicating that POPs can induce oxidative stress through the generation of ROS. Additionally, transcript profiles of genes related to detoxification #e.g., CYPs#, antioxidant functions #e.g., GST-sigma, catalase, MnSOD#, apoptosis #e.g., p53, Rb#, and cellular proliferation #e.g., PCNA# were modulated over 72 h in response to BDE-47 #120 mu g/L# and PFOS #1000 mu g/L#.These findings indicate that BDE-47 and PFOS can induce oxidative stress-mediated DNA damage repair systems with transcriptional regulation of detoxification, antioxidant, and apoptosis-related genes, resulting in developmental retardation and reduced fecundity in the copepod T. japonicus. #C# 2015 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by a grant of the Ministry of Oceans and Fisheries, Korea (Development of techniques for assessment and management of hazardous chemicals in the marine environment; 20140342) funded to Jae-Seong Lee and was also partly supported by a grant for the project Korea-Polar Ocean Development: K-POD (project no. PM13030) funded by the Ministry of Oceans and Fisheries, Korea. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.subject | Persistent organic pollutants | en_US |
dc.subject | Copepod | en_US |
dc.subject | Tigriopus japonicus | en_US |
dc.subject | Reactive oxygen species | en_US |
dc.subject | Developmental retardation | en_US |
dc.subject | Reduced fecundity | en_US |
dc.title | Developmental retardation, reduced fecundity, and modulated expression of the defensome in the intertidal copepod Tigriopus japonicus exposed to BDE-47 and PFOS | en_US |
dc.type | Article | en_US |
dc.relation.volume | 165 | - |
dc.identifier.doi | 10.1016/j.aquatox.2015.05.022 | - |
dc.relation.page | 136-143 | - |
dc.relation.journal | AQUATIC TOXICOLOGY | - |
dc.contributor.googleauthor | Han, Jeonghoon | - |
dc.contributor.googleauthor | Won, Eun-Ji | - |
dc.contributor.googleauthor | Lee, Min-Chul | - |
dc.contributor.googleauthor | Seo, Jung Soo | - |
dc.contributor.googleauthor | Lee, Su-Jae | - |
dc.contributor.googleauthor | Lee, Jae-Seong | - |
dc.relation.code | 2015002026 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | sj0420 | - |
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