Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최제민 | - |
dc.date.accessioned | 2016-10-12T01:24:02Z | - |
dc.date.available | 2016-10-12T01:24:02Z | - |
dc.date.issued | 2015-04 | - |
dc.identifier.citation | INTERNATIONAL IMMUNOPHARMACOLOGY, v. 25, NO 2, Page. 285-292 | en_US |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.issn | 1878-1705 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S1567576915000466 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/23763 | - |
dc.description.abstract | Piceatannol, a metabolite of resveratrol found in red wine and grapes, displays a wide spectrum of biological activity. Although the anti-oxidant, anti-inflammatory, and anti-tumorigenesis activity of piceatannol has been extensively studied, its role in the adaptive immune response has received less attention. Here we investigated the role of piceatannol, a well-known Syk inhibitor, in T cell activation, proliferation, and differentiation using isolated murine splenic T cells from C57BL/6 mice. Piceatannol treatment inhibited surface expression of CD4 and CD8 T cell activation markers CD25 and CD69, reduced production of cytokines IFN gamma, IL-2, and IL-17, and suppressed proliferation of activated T cells. Moreover, piceatannol treatment significantly inhibited differentiation of CD4(+)CD25(-)CD62L(+) naive CD4 T cells into Th1, Th2, and Th17 cells, presumably due to inhibition of TcR signaling through p-Erk, p-Akt, and p-p38. Piceatannol appears to be a useful nutritional or pharmacological biomolecule that regulates effector T cell functions such as cytokine production, differentiation, and proliferation. (C) 2015 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | This study is supported by the Basic Science Research Program through the grants from the National Research Foundation of Korea (NRF-2013R1A1A2A10060048) and Hanyang University (HY-2011-00000001004). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.subject | Piceatannol | en_US |
dc.subject | T cells | en_US |
dc.subject | TcR signaling | en_US |
dc.subject | T cell proliferation | en_US |
dc.subject | T cell differentiation | en_US |
dc.title | Piceatannol inhibits effector T cell functions by suppressing TcR signaling | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 25 | - |
dc.identifier.doi | 10.1016/j.intimp.2015.01.030 | - |
dc.relation.page | 285-292 | - |
dc.relation.journal | INTERNATIONAL IMMUNOPHARMACOLOGY | - |
dc.contributor.googleauthor | Kim, Do-Hyun | - |
dc.contributor.googleauthor | Lee, Yong-Gab | - |
dc.contributor.googleauthor | Park, Hong-Jai | - |
dc.contributor.googleauthor | Lee, Jung-Ah | - |
dc.contributor.googleauthor | Kim, Hyun Jung | - |
dc.contributor.googleauthor | Hwang, Jae-Kwan | - |
dc.contributor.googleauthor | Choi, Je-Min) | - |
dc.relation.code | 2015002418 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | jeminchoi | - |
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