Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최정순 | - |
dc.date.accessioned | 2016-08-29T02:22:01Z | - |
dc.date.available | 2016-08-29T02:22:01Z | - |
dc.date.issued | 2015-03 | - |
dc.identifier.citation | NEUROLOGY, v. 84, NO 11, Page. 1080-1089 | en_US |
dc.identifier.issn | 0028-3878 | - |
dc.identifier.issn | 1526-632X | - |
dc.identifier.uri | http://www.neurology.org/content/84/11/1080.short | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/22805 | - |
dc.description.abstract | Objective:To investigate whether prestroke antiplatelet agent (PA) use was associated with initial stroke severity.Methods:This was a retrospective, case-control study based on data from a prospectively collected hospital-based stroke registry (Korea University Stroke Registry). A total of 3,025 patients who were admitted with a diagnosis of first-ever ischemic stroke within 5 days of symptom onset were included. Stroke severity was measured with the NIH Stroke Scale (NIHSS). NIHSS score 4 at admission was categorized as mild stroke. Patients from the PA group were matched with those from the non-PA group using estimated propensity scores at a 1:1 ratio. Stepwise multivariable logistic regression analyses were performed on patients in the matched datasets with initial mild stroke.Results:Patients' mean age was 66.3 13.0 years, and 1,850 were men (61.5%). A total of 748 patients had been taking antiplatelet agents prior to stroke onset; 644 patients (86.1%) were taking a single antiplatelet agent. Among these agents, aspirin (83.7%) was the most common. A total of 102 patients (13.6%) were taking 2 antiplatelet agents. Multivariable analysis after propensity score matching demonstrated that PA use was associated with initial mild stroke (odds ratio 1.344; 95% confidence interval 1.014-1.782).Conclusions:PA use was associated with decreased first-ever stroke severity, suggesting that it has a beneficial effect.Classification of evidence:This study provides Class II evidence that prestroke use of antiplatelet agents reduces stroke severity in patients with first-ever acute ischemic stroke. | en_US |
dc.description.sponsorship | Samjin Pharmaceutical Company Ltd. | en_US |
dc.language.iso | en | en_US |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | en_US |
dc.subject | TREATMENT TOAST | en_US |
dc.subject | SEVERITY | en_US |
dc.subject | ASPIRIN | en_US |
dc.subject | TRIAL | en_US |
dc.subject | OUTCOMES | en_US |
dc.subject | ASSOCIATION | en_US |
dc.subject | STATINS | en_US |
dc.subject | DISEASE | en_US |
dc.subject | CLASSIFICATION | en_US |
dc.subject | TOLERANCE | en_US |
dc.title | Prestroke antiplatelet agents in first-ever ischemic stroke Clinical effects | en_US |
dc.type | Article | en_US |
dc.relation.no | 11 | - |
dc.relation.volume | 84 | - |
dc.identifier.doi | 10.1212/WNL.0000000000001361 | - |
dc.relation.page | 1080-1089 | - |
dc.relation.journal | NEUROLOGY | - |
dc.contributor.googleauthor | Jung, Jin-Man | - |
dc.contributor.googleauthor | Choi, Jungsoon | - |
dc.contributor.googleauthor | Eun, Mi-Yeon | - |
dc.contributor.googleauthor | Seo, Woo-Keun | - |
dc.contributor.googleauthor | Cho, Kyung-Hee | - |
dc.contributor.googleauthor | Yu, Sungwook | - |
dc.contributor.googleauthor | Oh, Kyungmi | - |
dc.contributor.googleauthor | Hong, Soonwoong | - |
dc.contributor.googleauthor | Park, Kwang-Yeol | - |
dc.relation.code | 2015001875 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF MATHEMATICS | - |
dc.identifier.pid | jungsoonchoi | - |
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