Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신인철 | - |
dc.date.accessioned | 2016-07-29T06:01:24Z | - |
dc.date.available | 2016-07-29T06:01:24Z | - |
dc.date.issued | 2015-02 | - |
dc.identifier.citation | MOLECULAR CANCER RESEARCH, v. 13, NO 2, Page. 319-329 | en_US |
dc.identifier.issn | 1557-3125 | - |
dc.identifier.issn | 1541-7786 | - |
dc.identifier.uri | http://mcr.aacrjournals.org/content/13/2/319.abstract? | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/22324 | - |
dc.description.abstract | Several groups have reported that TGF beta 1 regulates cellular responses to gamma-irradiation; however, the exact mechanism has not been fully elucidated. In the current study, the role of TGF beta 1 in cellular responses to gamma-irradiation was investigated in detail. The data indicate that TGF beta 1 pretreatment decreased the aftermath of ionizing radiation (IR)-induced DNA damage in a SMAD-dependent manner. To determine the underlying mechanism for these effects, the extent of IR-induced DNA repair activity in the presence or absence of TGF beta 1 was examined. Studies reveal that TGF beta 1 upregulated DNA ligase IV (Lig4), augmented IR-induced nuclear retention of the DNA ligase, and enhanced nonhomologous end-joining (NHEJ) repair activity. In addition, knockdown of Lig4 reduced the TGF beta 1-induced protection against IR. Overall, these data indicate that TGF beta 1 facilitates the NHEJ repair process upon gamma-irradiation and thereby enhances long-term survival. (C) 2014 AACR. | en_US |
dc.description.sponsorship | Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education | en_US |
dc.language.iso | en | en_US |
dc.publisher | AMER ASSOC CANCER RESEARCH | en_US |
dc.subject | DOUBLE-STRAND BREAKS | en_US |
dc.subject | TGF-BETA | en_US |
dc.subject | DNA-REPAIR | en_US |
dc.subject | MESENCHYMAL TRANSITION | en_US |
dc.subject | GENOMIC INSTABILITY | en_US |
dc.subject | IONIZING-RADIATION | en_US |
dc.subject | EPITHELIAL-CELLS | en_US |
dc.subject | CYCLE ARREST | en_US |
dc.subject | KINASE | en_US |
dc.subject | P53 | en_US |
dc.title | TGF beta 1 Protects Cells from gamma-IR by Enhancing the Activity of the NHEJ Repair Pathway | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 13 | - |
dc.identifier.doi | 10.1158/1541-7786.MCR-14-0098-T | - |
dc.relation.page | 319-329 | - |
dc.relation.journal | MOLECULAR CANCER RESEARCH | - |
dc.contributor.googleauthor | Kim, Mi-Ra | - |
dc.contributor.googleauthor | Lee, Jeeyong | - |
dc.contributor.googleauthor | An, You Sun | - |
dc.contributor.googleauthor | Jin, Yeung Bae | - |
dc.contributor.googleauthor | Park, In-Chul | - |
dc.contributor.googleauthor | Chung, Eunkyung | - |
dc.contributor.googleauthor | Shin, Incheol | - |
dc.contributor.googleauthor | Barcellos-Hoff, Mary Helen | - |
dc.contributor.googleauthor | Yi, Jae Youn | - |
dc.relation.code | 2015001969 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | incheol | - |
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