Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics
- Title
- Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics
- Author
- 구세영
- Keywords
- Biological imaging; Carbon nanotubes; Fluorescence; Fluorescence imaging; Quantum dots
- Issue Date
- 2022-01-12
- Publisher
- AMER CHEMICAL SOC
- Citation
- CHEMICAL REVIEWS, v. 122, no 1, page. 209−268
- Abstract
- In vivo imaging in the second near-infrared window (NIR-II, 1000–1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types of inorganic/organic fluorophores that can be used for noninvasive NIR-IIa/IIb imaging (NIR-IIa, 1300–1400 nm; NIR-IIb, 1500–1700 nm) with near-zero tissue autofluorescence and deeper tissue penetration. This review provides an overview of the reports published to date on the design, properties, molecular imaging, and theranostics of inorganic/organic NIR-IIa/IIb fluorophores. First, we summarize the design concepts of the up-to-date functional NIR-IIa/IIb biomaterials, in the order of single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), and organic fluorophores (OFs). Then, these novel imaging modalities and versatile biomedical applications brought by these superior fluorescent properties are reviewed. Finally, challenges and perspectives for future clinical translation, aiming at boosting the clinical application progress of NIR-IIa and NIR-IIb imaging technology are highlighted.
- URI
- https://pubs.acs.org/doi/full/10.1021/acs.chemrev.1c00553https://repository.hanyang.ac.kr/handle/20.500.11754/192083
- ISSN
- 0009-2665; 1520-6890
- DOI
- https://doi.org/10.1021/acs.chemrev.1c00553
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > CHEMICAL AND MOLECULAR ENGINEERING(화학분자공학과) > Articles
- Files in This Item:
- 2022.1_구세영_Versatile Types of Inorganic,Organic NIR-IIa,IIb Fluorophores- From Strategic Design toward Molecular Imaging and Theranostics.pdfDownload
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