Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유혜현 | - |
dc.date.accessioned | 2024-08-05T07:09:25Z | - |
dc.date.available | 2024-08-05T07:09:25Z | - |
dc.date.issued | 2024-04-01 | - |
dc.identifier.citation | CHEMICO-BIOLOGICAL INTERACTIONS, v. 392, article no. 110927, page. 1-9 | en_US |
dc.identifier.issn | 0009-2797 | en_US |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0009279724000735?via%3Dihub | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/191279 | - |
dc.description.abstract | Aromatase inhibitors are commonly employed in the treatment of hormone-dependent breast cancers, and flavonoids have emerged as a promising alternative to existing drug classes with unfavorable side effects. In this study, we conducted in vitro investigations into CYP19A1 (aromatase) inhibitory potential of 14 flavonoids, including pinocembrin, sakuranetin, eriodictyol, liquiritigenin, naringenin, hesperetin, flavanone, baicalein, chrysin, nobiletin, luteolin, sinensetin, tricin, and primuletin. Flavonoids displaying inhibitory activity were further assessed using in silico tools, such as molecular docking to predict binding affinities, as well as SwissADME, admetSAR, and QED (Quantitative Estimate of Drug-likeness) for drug-likeness prediction. Flavonoids with IC50 values less than 10 mu M, pinocembrin, eriodictyol, naringenin, liquirtigenin, sakuranetin, and chrysin, exhibited favorable physicochemical properties and ADME profiles, suggesting their potential for development as novel flavonoid-based aromatase inhibitors. This study would provide valuable insights for the development of flavonoid-based aromatase inhibitors for the treatment of breast cancer. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (RS-2023-00217123 and 2021R1A2C1010428). | en_US |
dc.language | en_US | en_US |
dc.publisher | ELSEVIER IRELAND LTD | en_US |
dc.relation.ispartofseries | v. 392, article no. 110927;1-9 | - |
dc.subject | Aromatase | en_US |
dc.subject | Flavonoids | en_US |
dc.subject | Breast cancer | en_US |
dc.subject | Inhibitors | en_US |
dc.title | Evaluating flavonoids as potential aromatase inhibitors for breast cancer treatment: In vitro studies and in silico predictions | en_US |
dc.type | Article | en_US |
dc.relation.volume | 392 | - |
dc.identifier.doi | https://doi.org/10.1016/j.cbi.2024.110927 | en_US |
dc.relation.page | 110927-110927 | - |
dc.relation.journal | CHEMICO-BIOLOGICAL INTERACTIONS | - |
dc.contributor.googleauthor | Seo, Jeong In | - |
dc.contributor.googleauthor | Yu, Jun Sang | - |
dc.contributor.googleauthor | Zhang, Yonghui | - |
dc.contributor.googleauthor | Yoo, Hye Hyun | - |
dc.relation.code | 2024003418 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | yoohh | - |
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