Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유혜현 | - |
dc.date.accessioned | 2024-08-05T07:06:19Z | - |
dc.date.available | 2024-08-05T07:06:19Z | - |
dc.date.issued | 2024-03-11 | - |
dc.identifier.citation | BIOMEDICINE & PHARMACOTHERAPY, v. 173, article no. 116394, page. 1-6 | en_US |
dc.identifier.issn | 0753-3322 | en_US |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0753332224002786 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/191278 | - |
dc.description.abstract | Recently, anthelmintics have showcased versatile therapeutic potential in addressing various diseases, positioning them as promising candidates for drug repurposing. However, challenges such as low bioavailability and a lack of a solid pharmacokinetic basis impede successful repurposing. To overcome these flaws, we aimed to investigate the key pharmacokinetic factors of anthelmintics mainly focusing on the absorption, distribution, and metabolism profiles by employing niclosamide (NIC) as a model drug. The intestinal permeability of NIC is significantly influenced by solubility and doesn't function as a substrate for efflux transporters. It showed high plasma protein binding. Also, the metabolism study indicated that NIC would have low metabolic stability by extensively undergoing the intestinal glucuronidation. Additionally, we investigated the CYP-mediated drugdrug interaction potential of NIC in both direct and time-dependent ways. NIC showed strong inhibitory effects on CYP1A2 and CYP2C8 and is not likely to become a time-dependent inhibitor. Our findings could contribute to the identification of essential factors in the pharmacokinetics of anthelmintics, potentially facilitating their repositioning. | en_US |
dc.description.sponsorship | This research was supported by National Research Foundation of Korea (NRF) Grant funded by the Korea government (MSIT) (RS2023–00217123) and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (RS-2023–00271578). | en_US |
dc.language | en_US | en_US |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | en_US |
dc.relation.ispartofseries | v. 173, article no. 116394;1-6 | - |
dc.subject | Drug repurposing | en_US |
dc.subject | Niclosamide | en_US |
dc.subject | Absorption | en_US |
dc.subject | Metabolism | en_US |
dc.subject | Drug-drug interactions | en_US |
dc.title | Pharmacokinetic considerations for enhancing drug repurposing opportunities of anthelmintics: Niclosamide as a case study | en_US |
dc.type | Article | en_US |
dc.relation.volume | 173 | - |
dc.identifier.doi | https://doi.org/10.1016/j.biopha.2024.116394 | en_US |
dc.relation.page | 116394-116639 | - |
dc.relation.journal | BIOMEDICINE & PHARMACOTHERAPY | - |
dc.contributor.googleauthor | Seo, Jeong In | - |
dc.contributor.googleauthor | Jin, Geun-woo | - |
dc.contributor.googleauthor | Yoo, Hye Hyun | - |
dc.relation.code | 2024009002 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | yoohh | - |
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