Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최한곤 | - |
dc.date.accessioned | 2024-07-17T02:19:08Z | - |
dc.date.available | 2024-07-17T02:19:08Z | - |
dc.date.issued | 2024-06-17 | - |
dc.identifier.citation | Colloids and Surfaces B: Biointerfaces, v. 241, article no. 114044, page. 1-12 | en_US |
dc.identifier.issn | 0927-7765 | en_US |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0927776524003035 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/191199 | - |
dc.description.abstract | In this study, we aimed to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) and a solid selfnanoemulsifying granule system (S-SNEGS) to enhance the solubility and oral bioavailability of celecoxib. This process involved the preparation of a liquid SNEDDS (L-SNEDDS) and its subsequent solidification into a SSNEDDS and a S-SNEGS. The L-SNEDDS consisted of celecoxib (drug), Captex® 355 (Captex; oil), Tween® 80 (Tween 80; surfactant) and D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS; cosurfactant) in a weight ratio of 3.5:25:60:15 to produce the smallest nanoemulsion droplet size. The S-SNEDDS and S-SNEGS were prepared with L-SNEDDS/Ca-silicate/Avicel PH 101 in a weight ratio of 103.5:50:0 using a spray dryer and 103.5:50:100 using a fluid bed granulator, respectively. We compared the two novel developed systems and celecoxib powder based on their solubility, dissolution rate, physicochemical properties, flow properties and oral bioavailability in rats. S-SNEGS showed a significant improvement in solubility and dissolution rate compared to S-SNEDDS and celecoxib powder. Both systems had been converted from crystalline drug to amorphous form. Furthermore, S-SNEGS exhibited a significantly reduced angle of repose, compressibility index and Hausner ratio than S-SNEDDS, suggesting that S-SNEGS was significantly superior in flow properties. Compared to S-SNEDDS and celecoxib powder, S-SNEGS increased the oral bioavailability (AUC value) in rats by 1.3 and 4.5-fold, respectively. Therefore, S-SNEGS wolud be recommended as a solid self-nanoemulsifying system suitable for poorly water-soluble celecoxib. | en_US |
dc.description.sponsorship | This work was supported by grants from the National Research Foundation of South Korea (NRF), funded by the South Korean government (MEST) under [grant numbers: 2022R1A2C2004197 and RS2023–00208448]. The authors are grateful to Center for Bio-Medical Engineering Core Facility (Dankook University) for providing FT-IR experiments. | en_US |
dc.language | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.ispartofseries | v. 241, article no. 114044;1-12 | - |
dc.subject | Celecoxib | en_US |
dc.subject | Solid self-nanoemulsifying drug delivery system | en_US |
dc.subject | Solid self-nanoemulsifying granule system | en_US |
dc.subject | Solubility | en_US |
dc.subject | Flow properties | en_US |
dc.subject | Oral bioavailability | en_US |
dc.title | Comparison of two self-nanoemulsifying drug delivery systems using different solidification techniques for enhanced solubility and oral bioavailability of poorly water-soluble celecoxib | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.colsurfb.2024.114044 | en_US |
dc.relation.page | 114044-114055 | - |
dc.relation.journal | Colloids and Surfaces B: Biointerfaces | - |
dc.contributor.googleauthor | Woo, Mi Ran | - |
dc.contributor.googleauthor | Woo, Sanghyun | - |
dc.contributor.googleauthor | Bak, Young-Woo | - |
dc.contributor.googleauthor | Cheon, Seunghyun | - |
dc.contributor.googleauthor | Kim, Jung Suk | - |
dc.contributor.googleauthor | Ji, Sang Hun | - |
dc.contributor.googleauthor | Park, Seonghyeon | - |
dc.contributor.googleauthor | Kim, Jong Oh | - |
dc.contributor.googleauthor | Jin, Sung Giu | - |
dc.contributor.googleauthor | Choi, Han-Gon | - |
dc.relation.code | 2024023204 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | hangon | - |
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