Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김재용 | - |
dc.date.accessioned | 2024-07-03T01:49:38Z | - |
dc.date.available | 2024-07-03T01:49:38Z | - |
dc.date.issued | 2022-11-22 | - |
dc.identifier.citation | HELIYON, v. 8, no 11, article no. 11597, page. 1-9 | en_US |
dc.identifier.issn | 2405-8440 | en_US |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S2405844022028857?via%3Dihub | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/191113 | - |
dc.description.abstract | Skeletal muscle atrophy is associated with many diseases including cancer, inflammatory diseases, neuromuscular diseases, and acute critical illness. Justicia procumbens L. has been used as a herbal remedy, but the pharmaco-logical effect of J. procumbens on muscle atrophy has not yet been reported. Herein, we investigate the anti -atrophic effect of the n-butanol fraction of J. procumbens (JPBuFr) on dexamethasone (DEX)-induced muscle at-rophy in C2C12 myotubes. The myotubes diameter, MHC positive area, ROS production, and mitochondria contents were observed under a fluorescence microscope, and various proteins related to degradation or synthesis were analyzed by western blots. JPBuFr significantly attenuated a reduction of myotube diameter, mitochondrial content, ATP level, myosin heavy chain, and myogenin expression induced by DEX. Furthermore, co-treatment of DEX and JPBuFr not only increased phosphorylation of Akt, mTOR, and p70S6K proteins but also decreased reactive oxygen species production and expression of protein degradation factors (MuRF1, Atrogin-1, FoxO3a) compared to DEX treatment. These results suggest that JPBuFr may provide potential protective effects against muscle atrophy, giving it potential for the development of anti-atrophic health functional foods. | en_US |
dc.description.sponsorship | Chul Young Kim was supported by National Research Foundation (Republic of Korea) [NRF-2020R1A2C1009455 & NRF-2020R1A6A1A0-3042854]. Jae-Yong Kim was supported by National Research Foundation (Republic of Korea) [NRF-2020R1I1A1A01069216]. | en_US |
dc.language | en_US | en_US |
dc.publisher | ELSEVIER SCI LTD | en_US |
dc.relation.ispartofseries | v. 8, no 11, article no. 11597;1-9 | - |
dc.subject | Justicia procumbens L. | en_US |
dc.subject | Muscle atrophy | en_US |
dc.subject | C2C12 | en_US |
dc.subject | Dexamethasone | en_US |
dc.subject | Protein degradation | en_US |
dc.title | Preventive effects of the butanol fraction of Justicia procumbens L. against dexamethasone-induced muscle atrophy in C2C12 myotubes | en_US |
dc.type | Article | en_US |
dc.relation.no | 11 | - |
dc.relation.volume | 8 | - |
dc.identifier.doi | https://doi.org/10.1016/j.heliyon.2022.e11597 | en_US |
dc.relation.page | 11597-11597 | - |
dc.relation.journal | HELIYON | - |
dc.contributor.googleauthor | Kim, Jae-Yong | - |
dc.contributor.googleauthor | Kim, Hye Mi | - |
dc.contributor.googleauthor | Kim, Ji Hoon | - |
dc.contributor.googleauthor | Lee, Ju-Hee | - |
dc.contributor.googleauthor | Zhang, Kaixuan | - |
dc.contributor.googleauthor | Guo, Shuo | - |
dc.contributor.googleauthor | Lee, Do Hyun | - |
dc.contributor.googleauthor | Gao, Eun Mei | - |
dc.contributor.googleauthor | Son, Rak Ho | - |
dc.contributor.googleauthor | Kim, Seong-Min | - |
dc.relation.code | 2022044436 | - |
dc.sector.campus | E | - |
dc.sector.daehak | RESEARCH INSTITUTE[E] | - |
dc.sector.department | INSTITUTE OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY | - |
dc.identifier.pid | kjaey0331 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.