Oral Nanomedicine: Challenges and Opportunities
- Title
- Oral Nanomedicine: Challenges and Opportunities
- Author
- 구세영
- Keywords
- bioavailability; biomedical applications; nanomaterials; nanomedicine; oral administration
- Issue Date
- 2023-09-19
- Publisher
- WILEY-V C H VERLAG GMBH
- Citation
- ADVANCED MATERIALS, v. 36, article no 2306081, page. 1-22
- Abstract
- Compared to injection administration, oral administration is free of discomfort, wound infection, and complications and has a higher compliance rate for patients with diverse diseases. However, oral administration reduces the bioavailability of medicines, especially biologics (e.g., peptides, proteins, and antibodies), due to harsh gastrointestinal biological barriers. In this context, the development and prosperity of nanotechnology have helped improve the bioactivity and oral availability of oral medicines. On this basis, first, the biological barriers to oral administration are discussed, and then oral nanomedicine based on organic and inorganic nanomaterials and their biomedical applications in diverse diseases are reviewed. Finally, the challenges and potential opportunities in the future development of oral nanomedicine, which may provide a vital reference for the eventual clinical transformation and standardized production of oral nanomedicine, are put forward.
- URI
- https://onlinelibrary.wiley.com/doi/10.1002/adma.202306081https://repository.hanyang.ac.kr/handle/20.500.11754/190616
- ISSN
- 0935-9648; 1521-4095
- DOI
- https://doi.org/10.1002/adma.202306081
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > CHEMICAL AND MOLECULAR ENGINEERING(화학분자공학과) > Articles
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