Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 주재열 | - |
dc.date.accessioned | 2024-05-29T06:56:37Z | - |
dc.date.available | 2024-05-29T06:56:37Z | - |
dc.date.issued | 2024-05-22 | - |
dc.identifier.citation | FRONTIERS IN PHARMACOLOGY, v. 15, no. 15, page. 1-20 | en_US |
dc.identifier.issn | 1663-9812 | en_US |
dc.identifier.uri | https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1403285/full | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/190430 | - |
dc.description.abstract | Ginseng leaves are known to contain high concentrations of bioactive compounds, such as ginsenosides, and have potential as a treatment for various conditions, including fungal infections, cancer, obesity, oxidative stress, and age-related diseases. This study assessed the impact of ginseng leaf extract (GLE) on mast cell-mediated allergic inflammation and atopic dermatitis (AD) in DNCB-treated mice. GLE reduced skin thickness and lymph node nodules and suppressed the expression and secretion of histamine and pro-inflammatory cytokines. It also significantly lowered the production of inflammatory response mediators including ROS, leukotriene C4 (LTC4), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS). GLE inhibited the phosphorylation of MAPKs (ERK, P38, JNK) and the activation of NF-κB, which are both linked to inflammatory cytokine expression. We demonstrated that GLE’s inhibitory effect on mast cell-mediated allergic inflammation is due to the blockade of the NF-κB and inflammasome pathways. Our findings suggest that GLE can be an effective therapeutic agent for mast-cell mediated and allergic inflammatory conditions. | en_US |
dc.description.sponsorship | The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Brain Research Program (NRF2019M3C7A1032551, SC), by the Basic Science Research Program (NRF-2022R1A2C1012142, SC), and by the Basic Science Research Program (NRF-2022R1I1A1A01070134, J-MO) through the National Research Foundation funded by the Korean government. | en_US |
dc.language | en_US | en_US |
dc.publisher | FRONTIERS MEDIA SA | en_US |
dc.relation.ispartofseries | v. 15, no. 15;1-20 | - |
dc.subject | ginseng leaf extract | en_US |
dc.subject | inflammasome | en_US |
dc.subject | pro-inflammatory cytokines | en_US |
dc.subject | degranulation | en_US |
dc.subject | MAPK | en_US |
dc.subject | NF-κB | en_US |
dc.subject | anti-inflammatory | en_US |
dc.title | Therapeutic potential of ginseng leaf extract in inhibiting mast cell-mediated allergic inflammation and atopic dermatitis-like skin inflammation in DNCB-treated mice | en_US |
dc.type | Article | en_US |
dc.relation.no | 15 | - |
dc.relation.volume | 15 | - |
dc.identifier.doi | 10.3389/fphar.2024.1403285 | en_US |
dc.relation.page | 1-20 | - |
dc.relation.journal | FRONTIERS IN PHARMACOLOGY | - |
dc.contributor.googleauthor | Oh, Jung-Mi | - |
dc.contributor.googleauthor | Yoon, HyunHo | - |
dc.contributor.googleauthor | Joo, Jae-Yeol | - |
dc.contributor.googleauthor | Im, Wan-Taek | - |
dc.contributor.googleauthor | Chun, Sungkun | - |
dc.relation.code | 2024002582 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | joojy | - |
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