Harnessing paper folding mechanism for reconfigurable DNA origami
- Title
- Harnessing paper folding mechanism for reconfigurable DNA origami
- Author
- 이찬석; Lee, Chanseok; Jeon, Kyounghwa; Lee, Jae Young; Kim, Young-Joo; Lee, Jae Gyung; Kim, Hyunsu; Cho, Maenghyo; Kim, Do-Nyun
- Issue Date
- 2023-07-05
- Publisher
- NATURE PORTFOLIO
- Citation
- NATURE, v. 619, pages78–86
- Abstract
- The paper-folding mechanism has been widely adopted in building of reconfgurable macroscale systems because of its unique capabilities and advantages in programming variable shapes and stifness into a structure1–5. However, it has barely been exploited in the construction of molecular-level systems owing to the lack of a suitable design principle, even though various dynamic structures based on DNA self-assembly6–9 have been developed10–23. Here we propose a method to harness the paper-folding mechanism to create reconfgurable DNA origami structures. The main idea is to build a reference, planar wireframe structure24 whose edges follow a crease pattern in paper folding so that it can be folded into various target shapes. We realized several paper-like folding and unfolding patterns using DNA strand displacement25 with high
yield. Orthogonal folding, repeatable folding and unfolding, folding-based microRNA detection and fuorescence signal control were demonstrated. Stimuli-responsive folding and unfolding triggered by pH or light-source change were also possible. Moreover, by employing hierarchical assembly26 we could expand the design space and complexity of the paper-folding mechanism in a highly programmable manner. Because of its high programmability and scalability, we expect that the proposed paper-folding-based reconfguration method will advance the development of complex molecular systems.
- URI
- https://information.hanyang.ac.kr/#/eds/detail?an=edssjs.2A279421&dbId=edssjshttps://repository.hanyang.ac.kr/handle/20.500.11754/190392
- ISSN
- 0028-0836; 1476-4687
- DOI
- 10.1038/s41586-023-06181-7
- Appears in Collections:
- COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > BIONANO ENGINEERING(생명나노공학과) > Articles
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML