Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 문효방 | - |
dc.date.accessioned | 2023-12-21T07:54:42Z | - |
dc.date.available | 2023-12-21T07:54:42Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.citation | Environmental Science & Technology, v. 57, NO. 41, Page. 15644.0-15655.0 | - |
dc.identifier.issn | 0013-936X;1520-5851 | - |
dc.identifier.uri | https://pubs.acs.org/doi/10.1021/acs.est.3c04311 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/187686 | - |
dc.description.abstract | Major aryl hydrocarbon receptor (AhR) agonists were identified in extracts of blubber, liver, and muscle from six long-beaked common dolphins (Delphinus capensis) and one fin whale (Balaenoptera physalus) collected from Korean coastal waters using effect-directed analysis. Results of the H4IIE-luc bioassay indicated that the polar fractions of blubber and liver extracts from the fin whale exhibited relatively high AhR-mediated potencies. Based on full-scan screening with high-resolution mass spectrometry, 37 AhR agonist candidates, spanning four use categories: pharmaceuticals, pesticides, cosmetics, and natural products, were selected. Among these, five polar AhR agonists were newly identified through toxicological confirmation. Concentrations of polar AhR agonists in cetaceans were tissue-specific, with extracts of blubber and liver containing greater concentrations than muscle extracts. Polar AhR agonists with great log K OA values (>5) were found to biomagnify in the marine food chain potentially. Polar AhR agonists contributed 8.9% of the observed AhR-mediated potencies in blubber and 49% in liver. Rutaecarpine and alantolactone contributed significantly to the total AhR-mediated potencies of blubber, whereas hydrocortisone was a major AhR contributor in the liver of the fin whale. This study is the first to identify the tissue-specific accumulation of polar AhR agonists in blubber and liver extracts of cetaceans. | - |
dc.description.sponsorship | This study was supported by grants from the National Research Foundation of Korea (2021R1C1C1005977 and 2022R1A4A1033825) and the Korea Institute of Marine Science & Technology Promotion (KIMST) funded by the Ministry of Oceans and Fisheries (2021-0427, 2022-0534, and RS-2023-00256330). The research was supported by a Discovery Grant from the Natural Science and Engineering Research Council of Canada (Project # 326415-07). The research published in this paper is part of the project titled "Next generation solutions to ensure healthy water resources for future generations" funded by the Global Water Futures program, Canada First Research Excellence Fund. Additional information is available at www.globalwaterfutures.ca. Prof. Giesy was supported by the Canada Research Chair program, a Distinguished Visiting Professorship in the Department of Environmental Sciences, Baylor University, in Waco, TX. | - |
dc.language | en | - |
dc.publisher | American Chemical Society | - |
dc.subject | cetaceans | - |
dc.subject | aryl hydrocarbon receptor-mediatedactivity | - |
dc.subject | H4IIE-luc transactivation bioassay | - |
dc.subject | biomagnification | - |
dc.subject | full-scan screening | - |
dc.subject | marinemammals | - |
dc.subject | hierarchical clustering analysis | - |
dc.title | Identification of Mid-Polar and Polar AhR Agonists in Cetaceans from Korean Coastal Waters: Application of Effect-Directed Analysis with Full-Scan Screening | - |
dc.type | Article | - |
dc.relation.no | 41 | - |
dc.relation.volume | 57 | - |
dc.identifier.doi | 10.1021/acs.est.3c04311 | - |
dc.relation.page | 15644.0-15655.0 | - |
dc.relation.journal | Environmental Science & Technology | - |
dc.contributor.googleauthor | Cha, Jihyun | - |
dc.contributor.googleauthor | Hong, Seongjin | - |
dc.contributor.googleauthor | Lee, Junghyun | - |
dc.contributor.googleauthor | Gwak, Jiyun | - |
dc.contributor.googleauthor | Kim, Mungi | - |
dc.contributor.googleauthor | Mok, Sori | - |
dc.contributor.googleauthor | Moon, Hyo-Bang | - |
dc.contributor.googleauthor | Jones, Paul D. | - |
dc.contributor.googleauthor | Giesy, John P. | - |
dc.contributor.googleauthor | Khim, Jong Seong | - |
dc.sector.campus | E | - |
dc.sector.daehak | 과학기술융합대학 | - |
dc.sector.department | 해양융합공학과 | - |
dc.identifier.pid | hbmoon | - |
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