Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 하정미 | - |
dc.date.accessioned | 2023-08-23T01:16:38Z | - |
dc.date.available | 2023-08-23T01:16:38Z | - |
dc.date.issued | 2010-09 | - |
dc.identifier.citation | TETRAHEDRON LETTERS, v. 51, NO. 38, Page. 4942-4946 | - |
dc.identifier.issn | 0040-4039 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0040403910013286?via%3Dihub | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/186143 | - |
dc.description.abstract | Naturally occurring L-783277 which belongs to 14-membered resorcylic acid lactones (RALs) turned out to be a potent kinase inhibitor against MEK (MAP kinase kinase). We successfully accomplished efficient and enantioselective total synthesis of L-783277 based on convergent assembly of one aromatic unit and two chiral building blocks with efficient orthogonal protection-deprotection strategy. Three key steps composed of olefin cross metathesis, addition of acetylene derivative to aldehyde, and Yamaguchi macrolactonization were subsequently employed to construct the framework of L-783277. The optical rotation value of L-783277 is for the first time presented in this Letter. (C) 2010 Elsevier Ltd. All rights reserved. | - |
dc.description.sponsorship | This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MODHRD, KRF-2007- 355-C00027). | - |
dc.language | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | enantioselectivity | - |
dc.subject | synthesis | - |
dc.subject | unclassified drug | - |
dc.subject | chirality | - |
dc.subject | aldehyde | - |
dc.subject | lactone derivative | - |
dc.subject | article | - |
dc.subject | deprotection reaction | - |
dc.subject | alkene | - |
dc.subject | l 783277 | - |
dc.subject | macrolactonization | - |
dc.subject | acetylene | - |
dc.title | An efficient and enantioselective total synthesis of naturally occurring L-783277 | - |
dc.type | Article | - |
dc.relation.no | 38 | - |
dc.relation.volume | 51 | - |
dc.identifier.doi | 10.1016/j.tetlet.2010.07.122 | - |
dc.relation.page | 4942-4946 | - |
dc.relation.journal | TETRAHEDRON LETTERS | - |
dc.contributor.googleauthor | Choi, Hwan Geun | - |
dc.contributor.googleauthor | Son, Jung Beom | - |
dc.contributor.googleauthor | Park, Dong-Sik | - |
dc.contributor.googleauthor | Ham, Young Jin | - |
dc.contributor.googleauthor | Hah, Jung-Mi | - |
dc.contributor.googleauthor | Sim, Taebo | - |
dc.sector.campus | E | - |
dc.sector.daehak | 약학대학 | - |
dc.sector.department | 약학과 | - |
dc.identifier.pid | jhah | - |
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