Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 하정미 | - |
dc.date.accessioned | 2023-08-23T01:14:57Z | - |
dc.date.available | 2023-08-23T01:14:57Z | - |
dc.date.issued | 2013-04 | - |
dc.identifier.citation | BIOORGANIC & MEDICINAL CHEMISTRY, v. 21, NO. 8, Page. 2271-2285 | - |
dc.identifier.issn | 0968-0896;1464-3391 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0968089613001454?via%3Dihub | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/186135 | - |
dc.description.abstract | 1-Heteroaryl-2-aryl-1H-benzimidazole derivatives were synthesized as inhibitors of c-Jun N-terminal kinases, JNK3. Their activities were evaluated through measurement of K-d using SPR, JNK3 kinase assay, and cell-viability of human neuroblastoma cells. Most tested compounds showed high affinity (10 mu M-46 nM) to JNK3. Among them, compound 16f exhibited potent activities (K-d = 46 nM). Especially, 16f was also found to present a potent cell protective effect (IC50 = 1.09 mu M) against toxicity induced by anisomycin, showing a possibility as protective therapeutics in neuronal cell apoptosis. (C) 2013 Elsevier Ltd. All rights reserved. | - |
dc.language | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | Benzimidazole | - |
dc.subject | Neuroprotective effect | - |
dc.subject | Neurodegenerative disease | - |
dc.subject | Neuroblastoma cell line | - |
dc.subject | Kinase inhibitor | - |
dc.subject | JNK | - |
dc.title | Syntheses and biological evaluation of 1-heteroaryl-2-aryl-1H-benzimidazole derivatives as c-Jun N-terminal kinase inhibitors with neuroprotective effects | - |
dc.type | Article | - |
dc.relation.no | 8 | - |
dc.relation.volume | 21 | - |
dc.identifier.doi | 10.1016/j.bmc.2013.02.021 | - |
dc.relation.page | 2271-2285 | - |
dc.relation.journal | BIOORGANIC & MEDICINAL CHEMISTRY | - |
dc.contributor.googleauthor | Kim, Mi-hyun | - |
dc.contributor.googleauthor | Lee, Junghun | - |
dc.contributor.googleauthor | Jung, Kyungjin | - |
dc.contributor.googleauthor | Kim, Minjung | - |
dc.contributor.googleauthor | Park, Yun-Jin | - |
dc.contributor.googleauthor | Ahn, Heechul | - |
dc.contributor.googleauthor | Kwon, Young Hye | - |
dc.contributor.googleauthor | Hah, Jung-Mi | - |
dc.sector.campus | E | - |
dc.sector.daehak | 약학대학 | - |
dc.sector.department | 약학과 | - |
dc.identifier.pid | jhah | - |
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