Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 하정미 | - |
dc.date.accessioned | 2023-08-23T01:14:29Z | - |
dc.date.available | 2023-08-23T01:14:29Z | - |
dc.date.issued | 2015-06 | - |
dc.identifier.citation | CHEMISTRY-AN ASIAN JOURNAL, v. 10, NO. 6, Page. 1318-1326 | - |
dc.identifier.issn | 1861-4728;1861-471X | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/10.1002/asia.201403417 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/186131 | - |
dc.description.abstract | As a way to develop a neuroprotective agent for the JNK3-JIP1-binding site, peptidomimetics of JIP-1 as JNK3 allosteric regulators have been examined. The study consisted of in silico scaffold hopping, molecular docking, solution and solid-phase peptide syntheses, and K-d measurements using surface plasmon resonance. As a peptidomimetic of JIP1, heptamer mimetic 16 (K-d=2.72m) displayed a higher affinity than decamer JIP1 (K-d=23.6m). The high affinity of 16 implies that the characteristic -turn mimetic structure, phi-X-phi hydrophobic motif in 16, increased its affinity toward the JIP-site of JNK3. | - |
dc.language | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | allosteric | - |
dc.subject | gamma turn | - |
dc.subject | JNK3 | - |
dc.subject | kinase inhibitors | - |
dc.subject | peptidomimetics | - |
dc.subject | scaffold hopping | - |
dc.title | De Novo Design and Synthesis of a -Turn Peptidomimetic Scaffold and Its Application as JNK3 Allosteric Ligand | - |
dc.type | Article | - |
dc.relation.no | 6 | - |
dc.relation.volume | 10 | - |
dc.identifier.doi | 10.1002/asia.201403417 | - |
dc.relation.page | 1318-1326 | - |
dc.relation.journal | CHEMISTRY-AN ASIAN JOURNAL | - |
dc.contributor.googleauthor | Kim, Mi-hyun | - |
dc.contributor.googleauthor | Lee, Junghun | - |
dc.contributor.googleauthor | Hah, Jung-Mi | - |
dc.sector.campus | E | - |
dc.sector.daehak | 약학대학 | - |
dc.sector.department | 약학과 | - |
dc.identifier.pid | jhah | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.