Solution Structure of pA2, the Mimotopic Peptide of Apolipoprotein A-I, by NMR Spectroscopy
- Title
- Solution Structure of pA2, the Mimotopic Peptide of Apolipoprotein A-I, by NMR Spectroscopy
- Author
- 원호식
- Keywords
- Apolipoprotein A-I; NMR spectroscopy; Molecular dynamic computation
- Issue Date
- 2011-11
- Publisher
- 대한화학회
- Citation
- Bulletin of the Korean Chemical Society, v. 32, NO. 11, Page. 4016-4020
- Abstract
- A number of mimetic peptides of apolipoprotein A-I, a major component for high density lipoproteins (HDL), were screened from the phase-displayed random peptide library by utilizing monoclonal antibodies (A12). A mimetic peptide for A12 epitope against apolipoprotein A-I was selected as FVLVRDTFPSSVCCP(pA2) exhibiting 45% homology with Apo A-I in the BLAST search. Solution structure determination of this mimotope was made by using 2D-NMR data and NMR-based distance geometry (DG)/molecular dynamic calculations. The resulting DG structures had low penalty value of 0.4-0.6 angstrom(2) and the total RMSD of 0.7-1.7 angstrom. The mimotope pA2 exhibited a characteristic beta-turn conformation from Val[2] to Phe[8] near Pro[9] residue.
- URI
- http://koreascience.or.kr/article/JAKO201101152704703.pagehttps://repository.hanyang.ac.kr/handle/20.500.11754/184137
- ISSN
- 0253-2964;1229-5949
- DOI
- 10.5012/bkcs.2011.32.11.4016
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > CHEMICAL AND MOLECULAR ENGINEERING(화학분자공학과) > Articles
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