Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조용우 | - |
dc.date.accessioned | 2023-07-17T01:17:35Z | - |
dc.date.available | 2023-07-17T01:17:35Z | - |
dc.date.issued | 2012-05 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF PHARMACEUTICS, v. 427, NO. 2, Page. 305-310 | - |
dc.identifier.issn | 0378-5173;1873-3476 | - |
dc.identifier.uri | https://linkinghub.elsevier.com/retrieve/pii/S0378517312001445 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/183758 | - |
dc.description.abstract | Carrier geometry is a key parameter of drug delivery systems and has significant impact on the drug release rate and interaction with cells and tissues. Here we present a piezoelectric inkjet printing system as a simple and convenient approach for fabrication of drug-loaded polymer microparticles with well-defined and controlled shapes. The physical properties of paclitaxel (PTX)-loaded poly(lactic-co-glycolic acid) (PLGA) inks, such as volatility, viscosity and surface tension, were optimized for piezoelectric inkjet printing, and PTX-loaded PLGA microparticles were fabricated with various geometries, such as circles, grids, honeycombs, and rings. The resulting microparticles with 10% (w/w) PTX exhibited a fairly homogeneous shape and size. The microparticle fabrication by piezoelectric inkjet printing was precise, reproducible, and highly favorable for mass production. The microparticles exhibited a biphasic release profile with an initial burst due to diffusion and a subsequent, slow second phase due to degradation of PLGA. The release rate was dependent on the geometry, mainly the surface area, with a descending rate order of honeycomb > grid, ring > circle. The PTX-loaded microparticles showed a comparable activity in inhibiting the growth of HeLa cells. Our results demonstrate that a piezoelectric inkjet printing system would provide a new approach for large-scale manufacturing of drug carriers with a desired geometry. (C) 2012 Elsevier B.V. All rights reserved. | - |
dc.language | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | Inkjet printing | - |
dc.subject | Microparticles | - |
dc.subject | Geometry | - |
dc.subject | Drug release | - |
dc.subject | In vitro cytotoxicity | - |
dc.title | Fabrication of drug-loaded polymer microparticles with arbitrary geometries using a piezoelectric inkjet printing system | - |
dc.type | Article | - |
dc.relation.no | 2 | - |
dc.relation.volume | 427 | - |
dc.identifier.doi | 10.1016/j.ijpharm.2012.02.011 | - |
dc.relation.page | 305-310 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.contributor.googleauthor | Lee, Byung Kook | - |
dc.contributor.googleauthor | Yun, Yeon Hee | - |
dc.contributor.googleauthor | Choi, Ji Suk | - |
dc.contributor.googleauthor | Choi, Young Chan | - |
dc.contributor.googleauthor | Kim, Jae Dong | - |
dc.contributor.googleauthor | Cho, Yong Woo | - |
dc.sector.campus | E | - |
dc.sector.daehak | 공학대학 | - |
dc.sector.department | 재료화학공학과 | - |
dc.identifier.pid | ywcho7 | - |
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