Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배옥남 | - |
dc.date.accessioned | 2023-06-23T02:26:50Z | - |
dc.date.available | 2023-06-23T02:26:50Z | - |
dc.date.issued | 2015-04 | - |
dc.identifier.citation | ARCHIVES OF DERMATOLOGICAL RESEARCH, v. 307, NO. 3, Page. 219.0-227.0 | - |
dc.identifier.issn | 0340-3696;1432-069X | - |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs00403-014-1529-8 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/182367 | - |
dc.description.abstract | Skin inflammation plays a central role in the pathophysiology and symptoms of diverse chronic skin diseases including atopic dermatitis (AD). In this study, we examined if caffeic acid phenethyl ester (CAPE), a skin-permeable bioactive compound from propolis, was protective against skin inflammation using in vitro cell system and in vivo animal disease models. CAPE suppressed TNF-alpha-induced NF-kappa B activation and expression of inflammatory cytokines in human keratinocytes (HaCaT). The potency and efficacy of CAPE were superior to those of a non-phenethyl derivative, caffeic acid. Consistently, topical treatment of CAPE (0.5 %) attenuated 12-O-tetradecanoylphorbol-13-acetate(TPA)-induced skin inflammation on mouse ear as CAPE reduced ear swelling and histologic inflammation scores. CAPE suppressed increased expression of pro-inflammatory molecules such as TNF-alpha, cyclooxygenase-2 and inducible NO synthase in TPA-stimulated skin. TPA-induced phosphorylation of I kappa B and ERK was blocked by CAPE suggesting that protective effects of CAPE on skin inflammation is attributed to inhibition of NF-kappa B activation. Most importantly, in an oxazolone-induced chronic dermatitis model, topical application of CAPE (0.5 and 1 %) was effective in alleviating AD-like symptoms such as increases of trans-epidermal water loss, skin thickening and serum IgE as well as histologic inflammation assessment. Collectively, our results propose CAPE as a promising candidate for a novel topical drug for skin inflammatory diseases. | - |
dc.language | en | - |
dc.publisher | SPRINGER | - |
dc.subject | Caffeic acid phenethyl ester (CAPE) | - |
dc.subject | Skin inflammation | - |
dc.subject | Nuclear factor kappa B (NF-kappa B) | - |
dc.subject | Atopic dermatitis | - |
dc.subject | TPA-induced ear edema | - |
dc.title | Suppression of skin inflammation in keratinocytes and acute/chronic disease models by caffeic acid phenethyl ester | - |
dc.type | Article | - |
dc.relation.no | 3 | - |
dc.relation.volume | 307 | - |
dc.identifier.doi | 10.1007/s00403-014-1529-8 | - |
dc.relation.page | 219.0-227.0 | - |
dc.relation.journal | ARCHIVES OF DERMATOLOGICAL RESEARCH | - |
dc.contributor.googleauthor | Lim, Kyung-Min | - |
dc.contributor.googleauthor | Bae, SeungJin | - |
dc.contributor.googleauthor | Koo, Jung Eun | - |
dc.contributor.googleauthor | Kim, Eun-Sun | - |
dc.contributor.googleauthor | Bae, Ok-Nam | - |
dc.contributor.googleauthor | Lee, Joo Young | - |
dc.sector.campus | E | - |
dc.sector.daehak | 약학대학 | - |
dc.sector.department | 약학과 | - |
dc.identifier.pid | onbae | - |
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