Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신경훈 | - |
dc.date.accessioned | 2023-06-01T00:49:35Z | - |
dc.date.available | 2023-06-01T00:49:35Z | - |
dc.date.issued | 2019-11 | - |
dc.identifier.citation | International Journal of Legal Medicine, v. 133, NO. 6, Page. 1785-1794 | - |
dc.identifier.issn | 0937-9827;1437-1596 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007/s00414-019-02052-x | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/181806 | - |
dc.description.abstract | Gamma (gamma)-hydroxybutyric acid (GHB) has been reported to be an endogenous compound in the mammalian brain. It used to treat symptoms of alcohol, opioid, and drug withdrawal and cataplexy of narcolepsy. However, it is often used for criminal purposes because it is colorless, tasteless, and has short half-life. For this reason, there is a need for a method of distinguishing between endogenous and exogenous GHB administration. Therefore, urine from rat before administration of GHB and GHB urine after the single intraperitoneal injection of GHB as 30 mg/100 g were collected from Sprague-Dawley rats (7 weeks old, 10 males and females). Negative control urine, urine from individuals suspected of taking GHB, and urine from victims who were GHB-involved crime were collected. In urine samples, GHB was extracted with two-step SPE and collected fraction was derivatized and analyzed by GC/MS and GC/C/IRMS. In GC/MS and GC/C/IRMS analysis of rat urine, there was a statistically significant difference between urine from rat before administration of GHB and GHB rat urine (p < 0.05). In GC/MS analysis of human urine samples, there was no significant difference among human urine groups (negative control, suspects' urine, and victims' urine), but in GC/C/IRMS analysis of human urine samples, there was a statistically significant difference among human urine groups (p = 0.0001). Through these results, GC/C/IRMS can be more effective tool to identify endogenous and exogenous GHB in urine than GC/MS. This study can build a drug management system in forensic investigation agency and offer interpretation method to forensic science and court. | - |
dc.description.sponsorship | National Forensic Service (NFS) 2017-04; Priority Research Centers Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology, Republic of Korea 2016R1A6A1A03007648 | - |
dc.language | en | - |
dc.publisher | Springer Verlag | - |
dc.subject | Gamma (gamma)-hydroxybutyric acid | - |
dc.subject | GHB | - |
dc.subject | Endogenous | - |
dc.subject | Exogenous | - |
dc.subject | GC | - |
dc.subject | MS | - |
dc.subject | GC/C/IRMS | - |
dc.subject | delta C-13 values | - |
dc.title | Differentiation of endogenous and exogenous gamma-Hydroxybutyrate in rat and human urine by GC/C/IRMS | - |
dc.type | Article | - |
dc.relation.no | 6 | - |
dc.relation.volume | 133 | - |
dc.identifier.doi | 10.1007/s00414-019-02052-x | - |
dc.relation.page | 1785-1794 | - |
dc.relation.journal | International Journal of Legal Medicine | - |
dc.contributor.googleauthor | Kim, Hyojeong | - |
dc.contributor.googleauthor | Lee, Dong-Hun | - |
dc.contributor.googleauthor | Go, Ahra | - |
dc.contributor.googleauthor | Park, Meejung | - |
dc.contributor.googleauthor | Choe, Sanggil | - |
dc.contributor.googleauthor | In, Sanghwan | - |
dc.contributor.googleauthor | Kim, Eunmi | - |
dc.contributor.googleauthor | Lee, Hunjoo | - |
dc.contributor.googleauthor | Shin, Kyung-Hoon | - |
dc.contributor.googleauthor | Han, Eunyoung | - |
dc.sector.campus | E | - |
dc.sector.daehak | 과학기술융합대학 | - |
dc.sector.department | 해양융합공학과 | - |
dc.identifier.pid | shinkh | - |
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