Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유봉영 | - |
dc.date.accessioned | 2023-05-19T07:28:43Z | - |
dc.date.available | 2023-05-19T07:28:43Z | - |
dc.date.issued | 2011-05 | - |
dc.identifier.citation | Journal of Nanoscience and Nanotechnology, v. 11, NO. 5, Page. 4592-4595 | - |
dc.identifier.issn | 1533-4880;1533-4899 | - |
dc.identifier.uri | https://www.ingentaconnect.com/content/asp/jnn/2011/00000011/00000005/art00142;jsessionid=2jpqeuv2iwqh.x-ic-live-01 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/180963 | - |
dc.description.abstract | Liposome encapsulating Fe3O4 (liposome complexes) has been prepared for targeting a drug to a specific organ, as well as for MRI (magnetic resonance imaging) contrast agents. The objective of the present work was to investigate the Fe3O4 properties and the effects of chitosan concentration on the characteristics of chitosan-coated liposome complexes. They were characterized by DLS, FT-IR, XRD, VSM, UV-Vis spectrometer, TEM and phase-contrast microscopy. The average liposome complex size was approximately 500 nm, with individual Fe3O4 nanoparticle sizes of 10 nm. The drug incorporation efficiency of trypsin in liposome complexes was 65-69%, the drug release was sustained and the incorporated drugs had the magnetization properties of the liposome complexes. Incorporation of chitosan into the liposonne bilayer decreased trypsin release from the liposome complexes due to an increased rigidity of the liposome membrane structure. Chitosan-coated liposome complexes showed a higher stability when compared with the stability of non-coated liposome complexes. | - |
dc.description.sponsorship | This work was supported by grants?in-aid for the National Core Research Center Program from MOST/KOSEF (No. R15-2006-022-03001-0) and supported by New & Renewable Energy R&D program (No: 2009T100100614) under the Ministry of Knowledge Economy, Republic of Korea. | - |
dc.language | en | - |
dc.publisher | American Scientific Publishers | - |
dc.subject | Fe3O4 Nanoparticle | - |
dc.subject | Chitosan | - |
dc.subject | Liposome Complexes | - |
dc.subject | MRI (Magnetic Resonance Imaging) Contrast Agents | - |
dc.subject | DDS (Drug Delivery System) | - |
dc.title | Characterization and Stability of Liposome-Enveloped Trypsin/Fe3O4 for Drug Delivery and Drug Release Behavior | - |
dc.type | Article | - |
dc.relation.no | 5 | - |
dc.relation.volume | 11 | - |
dc.identifier.doi | 10.1166/jnn.2011.3638 | - |
dc.relation.page | 4592-4595 | - |
dc.relation.journal | Journal of Nanoscience and Nanotechnology | - |
dc.contributor.googleauthor | Kim, Min-Jung | - |
dc.contributor.googleauthor | Jang, Dae-Hwan | - |
dc.contributor.googleauthor | Kim, Hak-Kyong | - |
dc.contributor.googleauthor | Lee, Young-In | - |
dc.contributor.googleauthor | Lee, Gun-Jae | - |
dc.contributor.googleauthor | Yoo, Bong-Young | - |
dc.contributor.googleauthor | Choa, Yong-Ho | - |
dc.sector.campus | E | - |
dc.sector.daehak | 공학대학 | - |
dc.sector.department | 재료화학공학과 | - |
dc.identifier.pid | byyoo | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.