Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 류종석 | - |
dc.date.accessioned | 2023-05-17T00:59:19Z | - |
dc.date.available | 2023-05-17T00:59:19Z | - |
dc.date.issued | 2015-03 | - |
dc.identifier.citation | Evidence-based Complementary and Alternative Medicine, v. 2015, article no. 608126, Page. 1.0-11.0 | - |
dc.identifier.issn | 1741-427X;1741-4288 | - |
dc.identifier.uri | https://www.hindawi.com/journals/ecam/2015/608126/ | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/180550 | - |
dc.description.abstract | In traditional Chinese medicine, Persicaria chinensis L. has been prescribed to cure numerous inflammatory disorders. We previously analyzed the bioactivity of the methanol extract of this plant (Pc-ME) against LPS-induced NO and PGE(2) in RAW264.7 macrophages and found that it preventedHCl/EtOH-induced gastric ulcers in mice. The purpose of the current study was to explore the molecular mechanism by which Pc-ME inhibits activator protein-(AP-) 1 activation pathway and mediates its hepatoprotective activity. To investigate the putative therapeutic properties of Pc-ME against AP-1-mediated inflammation and hepatotoxicity, lipopolysaccharide-(LPS-) stimulated RAW264.7 and U937 cells, a monocyte-like human cell line, and an LPS/D-galactosamine(D-GalN-) induced acute hepatitis mouse model were employed. The expression of LPS-induced proinflammatory cytokines including interleukin-(IL-) 1 beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha) was significantly diminished by Pc-ME. Moreover, Pc-ME reduced AP-1 activation and mitogen-activated protein kinase (MAPK) phosphorylation in both LPS-stimulated RAW264.7 cells and differentiated U937 cells. Additionally, we highlighted the hepatoprotective and curative effects of Pc-ME pretreated orally in a mouse model of LPS/D-GalN-intoxicated acute liver injury by demonstrating the significant reduction in elevated serum AST and ALT levels and histological damage. Therefore, these results strongly suggest that Pc-ME could function as an antihepatitis remedy suppressing MAPK/AP-1-mediated inflammatory events. | - |
dc.description.sponsorship | This study was supported by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI12C0050). | - |
dc.language | en | - |
dc.publisher | Oxford University Press | - |
dc.title | AP-1-Targeting Anti-Inflammatory Activity of the Methanolic Extract of Persicaria chinensis | - |
dc.type | Article | - |
dc.relation.volume | 2015 | - |
dc.identifier.doi | 10.1155/2015/608126 | - |
dc.relation.page | 1.0-11.0 | - |
dc.relation.journal | Evidence-based Complementary and Alternative Medicine | - |
dc.contributor.googleauthor | Hossen, Muhammad Jahangir | - |
dc.contributor.googleauthor | Kim, Seung Cheol | - |
dc.contributor.googleauthor | Son, Young-Jin | - |
dc.contributor.googleauthor | Baek, Kwang-Soo | - |
dc.contributor.googleauthor | Kim, Eunji | - |
dc.contributor.googleauthor | Yang, Woo Seok | - |
dc.contributor.googleauthor | Jeong, Deok | - |
dc.contributor.googleauthor | Park, Jae Gwang | - |
dc.contributor.googleauthor | Kim, Han Gyung | - |
dc.contributor.googleauthor | Chung, Woo-Jae | - |
dc.contributor.googleauthor | Yoon, Keejung | - |
dc.contributor.googleauthor | Ryou, Chongsuk | - |
dc.contributor.googleauthor | Lee, Sang Yeol | - |
dc.contributor.googleauthor | Kim, Jong-Hoon | - |
dc.contributor.googleauthor | Cho, Jae Youl | - |
dc.sector.campus | E | - |
dc.sector.daehak | 약학대학 | - |
dc.sector.department | 약학과 | - |
dc.identifier.pid | cryou2 | - |
dc.identifier.article | 608126 | - |
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