Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 이현규 | - |
dc.contributor.author | 윤다민 | - |
dc.date.accessioned | 2023-05-11T12:04:46Z | - |
dc.date.available | 2023-05-11T12:04:46Z | - |
dc.date.issued | 2023. 2 | - |
dc.identifier.uri | http://hanyang.dcollection.net/common/orgView/200000651676 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/180156 | - |
dc.description.abstract | Several studies confirmed that grain intake is associated with preventing type 2 diabetes mellitus (T2DM). However, the studies that examined the diabetes amelioration effect of whole grains with different processing treatments are limited. Here, we investigated the anti-diabetic effects of non-processed (raw), roasted, and extruded-puffed blended grains (BG) supplementation on 45 kcal% high-fat diet (HFD) to streptozotocin-nicotinamide (STZ-NA) induced diabetic rats for six weeks. BG was a blend of oat, sorghum, adzuki bean, finger millet, and proso millet in a ratio selected through preliminary research. A group of normal rats fed a standard diet (NC) and diabetic rats were assigned to four dietary groups: HFD (MC), HFD with 40% non-processed BG (NBG), roasted BG (RBG), and extruded-puffed BG (EPBG). As a result, no significant differences were exhibited after NBG, RBG, and EPBG administration in body weight, while the fasting blood glucose levels (FBG) were remarkably decreased in EPBG (p < 0.05). Moreover, we demonstrated EPBG remarkably improved glucose tolerance measured by oral glucose tolerance test (OGTT) and insulin resistance assessed with insulin tolerance test (ITT) compared with MC (p < 0.05). Glycosylated hemoglobin (HbA1c) levels were lower in NBG, RBG, and EPBG than in MC, and in particular, EPBG significantly decreased HbA1c levels compared to NBG and RBG (p < 0.05). NBG, RBG, and EPBG showed no significant differences in serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) compared to MC. EPBG improved degenerative pathological changes in the liver and pancreas and increased insulin immunoreactivities in pancreatic β-cells. In addition, EPBG dramatically down-regulated hepatic mRNA expressions of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) related to gluconeogenesis (p < 0.05). Taken together, EPBG mostly attenuates hyperglycemia, suggesting the potential of extruded-puffed BG as a new functional food rather than raw or roasted BG for T2DM management. | - |
dc.publisher | 한양대학교 | - |
dc.title | Effect of blended grains with different processing treatments on the anti-diabetic activity in type 2 diabetic rats | - |
dc.type | Theses | - |
dc.contributor.googleauthor | 윤다민 | - |
dc.contributor.alternativeauthor | Da Min Yun | - |
dc.sector.campus | S | - |
dc.sector.daehak | 대학원 | - |
dc.sector.department | 식품영양학과 | - |
dc.description.degree | Master | - |
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