Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 조천규 | - |
dc.contributor.author | 민혜원 | - |
dc.date.accessioned | 2023-05-11T11:44:04Z | - |
dc.date.available | 2023-05-11T11:44:04Z | - |
dc.date.issued | 2023. 2 | - |
dc.identifier.uri | http://hanyang.dcollection.net/common/orgView/200000652000 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/179490 | - |
dc.description.abstract | Subincanadine F is a novel indole alkaloid possessing a bridged medium-sized heterocyclic framework, isolated in 0.002% yield as a trifluoroacetic acid salt from a Brazilian medicinal plant, Aspidosperma subincanum. The 1-azabicyclo[4,3,1]decane skeleton embedded in this alkaloid imposes a formidable synthetic challenge. Recently, we found that perhydrocyclohepta[b]indole-6,7-diol can undergo a semi-pinacol-type rearrangement into ring-contracted 1-formyl perhydro-carbazole. Moreover, the asymmetric introduction of the 6,7-diol group effectively controlled the stereochemistry of the formyl group. The scope and limitation of this potentially useful alternative to Koser’s reagent-based method were investigated, along with the application to the asymmetric total synthesis of subincanadine F. | - |
dc.publisher | 한양대학교 | - |
dc.title | Studies toward Asymmetric Total Synthesis of Subincanadine F via semi-Pinacol Rearrangement | - |
dc.type | Theses | - |
dc.contributor.googleauthor | 민혜원 | - |
dc.sector.campus | S | - |
dc.sector.daehak | 대학원 | - |
dc.sector.department | 화학과 | - |
dc.description.degree | Master | - |
dc.contributor.affiliation | 유기화학 | - |
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