Selective preconcentration and online collection of charged molecules using ion concentration polarization
- Title
- Selective preconcentration and online collection of charged molecules using ion concentration polarization
- Author
- Jong Wook Hong
- Issue Date
- 2015-07
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- RSC ADVANCES, v. 5, NO. 81, Page. 66178-66184
- Abstract
- A multilayer micro/nanofluidic device was presented for the selective preconcentration and online collection of charged molecules with different physicochemical properties based on ion concentration polarization phenomena. With a balance of electroosmotic drag force and electrophoretic force on the molecules, a sample mixture of sulforhodamine B and Alexa Fluor 488 could be highly preconcentrated and separated simultaneously. A repeated microchamber structure was employed to capture each dye at a desirable position. For subsequent on-chip or off-chip application, pneumatic microvalves were integrated and selectively collected the target dyes with cyclic valve operations. Using the integrated system, Alexa Fluor 488 was solely collected (with a separation resolution of 1.75) out of the mixture at a 30-fold preconcentration ratio. This integrated device would be a key component for lab on a chip applications.
- URI
- https://pubs.rsc.org/en/content/articlelanding/2015/RA/C5RA12639Hhttps://repository.hanyang.ac.kr/handle/20.500.11754/178676
- ISSN
- 2046-2069
- DOI
- 10.1039/c5ra12639h
- Appears in Collections:
- COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > BIONANO ENGINEERING(생명나노공학과) > Articles
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