Gravity Applied Particle Separation in Nanoliter Volume Fluid System Toward Complexed Biosample Sorting
- Title
- Gravity Applied Particle Separation in Nanoliter Volume Fluid System Toward Complexed Biosample Sorting
- Author
- Jong Wook Hong
- Keywords
- Gravity Applied Separation; Microfluidics; Biosample Sorting; Density Separation
- Issue Date
- 2016-11
- Publisher
- AMER SCIENTIFIC PUBLISHERS
- Citation
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v. 16, NO. 11, Page. 11892-11895
- Abstract
- The separation of target molecules from complexed biosamples such as blood is essential for both biochemical understanding and pathological decision-making. As an alternative to conventional centrifugation, which has critical disadvantages, we suggest microgravitational particle separation under mild conditions to prevent distortion, lysis, and the breakage of biological particles. Polymer particles with similar sizes and different densities were used as models. We determined the optimum operating conditions, including the concentration of a sucrose solution and flow rate, based on Stokes law. A separation efficiency of more than 95% showed the potential of the designed microsystems for complexed biosample sorting.
- URI
- https://www.ingentaconnect.com/content/asp/jnn/2016/00000016/00000011/art00149https://repository.hanyang.ac.kr/handle/20.500.11754/178664
- ISSN
- 1533-4880;1533-4899
- DOI
- 10.1166/jnn.2016.13613
- Appears in Collections:
- COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > BIONANO ENGINEERING(생명나노공학과) > Articles
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