Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its Application for Membrane Protein Study
- Title
- Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its Application for Membrane Protein Study
- Author
- 채필석
- Keywords
- amphiphiles; membrane proteins; micelles; molecular design; protein stability; self-assembly
- Issue Date
- 2019-06
- Publisher
- Wiley - V C H Verlag GmbbH & Co.
- Citation
- Chemistry - An Asian Journal, v. 14, NO. 11, Page. 1926-1931
- Abstract
- We prepared an amphiphile with a penta-phenylene lipophilic group and a branched trimaltoside head group. This new agent, designated penta-phenylene maltoside (PPM), showed a marked tendency to self-assembly into micelles via strong aromatic-aromatic interactions in aqueous media, as evidenced by H-1 NMR spectroscopy and fluorescence studies. When utilized for membrane protein studies, this new agent was superior to DDM, a gold standard conventional detergent, in stabilizing multiple proteins long term. The ability of this agent to form aromatic-aromatic interactions is likely responsible for enhanced protein stabilization when associated with a target membrane protein.
- URI
- https://onlinelibrary.wiley.com/doi/10.1002/asia.201900224https://repository.hanyang.ac.kr/handle/20.500.11754/176095
- ISSN
- 1861-4728;1861-471X
- DOI
- 10.1002/asia.201900224
- Appears in Collections:
- COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > BIONANO ENGINEERING(생명나노공학과) > Articles
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