Low DUSP4 Expression Is Associated With Aggressive Phenotypes and Poor Prognosis in Gastric Cancer
- Title
- Low DUSP4 Expression Is Associated With Aggressive Phenotypes and Poor Prognosis in Gastric Cancer
- Author
- 최동호
- Keywords
- Gastric cancer; DUSP4; dual-specificity protein phosphatase 4; prognosis
- Issue Date
- 2021-02
- Publisher
- INT INST ANTICANCER RESEARCH
- Citation
- IN VIVO, v. 35, NO 1, Page. 131-140
- Abstract
- Background/Aim: Dual-specificity protein phosphatase 4 (DUSP4) negatively regulates MAPK signaling and is involved in various cellular processes. We herein evaluated the relationship between DUSP4 expression and clinicopathological characteristics in a large series of gastric cancer samples. Materials and Methods: DUSP4 expression was examined by immunohistochemistry in 508 gastric cancer samples. Cases were classified according to the TCGA molecular classification and HER2 amplification. Kaplan-Meier plots were used to predict the relationship between mRNA expression of DUSP4 and survival. Results: Low expression of DUSP4 was significantly correlated with larger tumor size, higher pT category, positive nodal status, higher stage, lymphovascular invasion, perineural invasion, worse overall survival, and worse recurrence-free survival. No correlation was observed between DUSP4 expression and molecular characteristics. Bioinformatics analysis showed that low mRNA expression was associated with a poor prognosis. Conclusion: Low expression of DUSP4 is associated with aggressive phenotypes of gastric cancer and a poor prognosis.
- URI
- https://iv.iiarjournals.org/content/35/1/131https://repository.hanyang.ac.kr/handle/20.500.11754/175788
- ISSN
- 0258-851X; 1791-7549
- DOI
- 10.21873/invivo.12240
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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