Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 차경준 | - |
dc.date.accessioned | 2022-10-21T00:56:55Z | - |
dc.date.available | 2022-10-21T00:56:55Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.citation | CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY, v. 14, NO 1, Page. 93-99 | en_US |
dc.identifier.issn | 2005-0720; 1976-8710 | en_US |
dc.identifier.uri | https://www.e-ceo.org/journal/view.php?doi=10.21053/ceo.2019.01921 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/175650 | - |
dc.description.abstract | Objectives. Sensitization to specific inhalant allergens is a major risk factor for the development of atopic diseases, which impose a major socioeconomic burden and significantly diminish quality of life. However, patterns of inhalant allergic sensitization have yet to be precisely described.Therefore, to enhance the understanding of aeroallergens, we performed a cluster analysis of inhalant allergic sensitization using a computational model. Methods. Skin prick data were collected from 7,504 individuals. A positive skin prick response was defined as an allergen to-histamine wheal ratio ˃= 1. To identify the clustering of inhalant allergic sensitization, we performed computational analysis using the four-parameter unified-Richards model. Results. Hierarchical cluster analysis grouped inhalant allergens into three clusters based on the Davies-Bouldin index (0.528): duster 1 (Dermatophagoides pteronyssinus and Dermatophagoides Prime), cluster 2 (mugwort, cockroach, oak, birch, cat, and dog), and cluster 3 (Alternaria tenus, ragweed, Candida albicans, Kentucky grass, and meadow grass). Computational modeling revealed that each allergen cluster had a different trajectory over the lifespan. Cluster 1 showed a high level (˃50%) of sensitization at an early age (before 19 years), followed by a sharp decrease in sensitization. Cluster 2 showed a moderate level (10%-20%) of sensitization before 29 years of age, followed by a steady decrease in sensitization. I lowever, cluster 3 revealed a low level (˂10%) of sensitization at all ages. Conclusion. Computational modeling suggests that allergic sensitization consists of three clusters with distinct patterns at different ages.The results of this study will be helpful to allergists in managing patients with atopic diseases. | en_US |
dc.description.sponsorship | This research was supported by the research fund of Hanyang University (HY-2015), a grant (2017R1D1A1B03028797) from the National Research Foundation of Korea funded by the Korea Ministry of Science, ICT, & Future Planning (MSIP), and by the Korea Ministry of Environment (MOE) through the Environmental Health Action Program (2016001360003). This research was also supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2020R1A6A1A06046728). | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN SOC OTORHINOLARYNGOL | en_US |
dc.subject | Allergen; Skin Test; Cluster Analysis; Computational Biology | en_US |
dc.title | Cluster Analysis of Inhalant Allergens in South Korea: A Computational Model of Allergic Sensitization | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 14 | - |
dc.identifier.doi | 10.21053/ceo.2019.01921 | en_US |
dc.relation.page | 93-99 | - |
dc.relation.journal | CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY | - |
dc.contributor.googleauthor | Kim, Dong-Kyu | - |
dc.contributor.googleauthor | Park, Young-Sun | - |
dc.contributor.googleauthor | Cha, Kyung-Joon | - |
dc.contributor.googleauthor | Jang, Daeil | - |
dc.contributor.googleauthor | Ryu, Seungho | - |
dc.contributor.googleauthor | Kim, Kyung Rae | - |
dc.contributor.googleauthor | Kim, Sang-Heon | - |
dc.contributor.googleauthor | Yoon, Ho Joo | - |
dc.contributor.googleauthor | Cho, Seok Hyun | - |
dc.relation.code | 2021001043 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF MATHEMATICS | - |
dc.identifier.pid | kjcha | - |
dc.identifier.orcid | https://orcid.org/0000-0003-2261-0785 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.