Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최제민 | - |
dc.date.accessioned | 2022-10-14T02:37:04Z | - |
dc.date.available | 2022-10-14T02:37:04Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.citation | ELIFE, v. 10, article no. 61841, page. 1-29 | en_US |
dc.identifier.issn | 2050-084X | en_US |
dc.identifier.uri | https://elifesciences.org/articles/61841 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/175390 | - |
dc.description.abstract | Derived from a common precursor cell, the balance between Th17 and Treg cells must be maintained within immune system to prevent autoimmune diseases. IL-1 beta-mediated IL-1 receptor (1L-1R) signaling is essential for Th17-cell biology. Fine-tuning of IL-1R signaling is controlled by two receptors, IL-1RI and IL-RII, IL-1R accessory protein, and IL-1R antagonist. We demonstrate that the dec oy receptor, IL-1RII, is important for regulating IL-17 responses in TCR-stimulated CD4(+) T cells expressing functional IL-1 RI via limiting IL-1 beta responsiveness. IL-1 RII expression is regulated by NFAT via its interaction with Foxp3. The NFAT/FOXP3 complex binds to the IL-1RII promoter and is critical for its transcription. Additionally, IL-1RII expression is dysregulated in CD4(+) T cells from patients with rheumatoid arthritis. Thus, differential expression of IL-1Rs on activated CD4(+) T cells defines unique immunological features and a novel molecular mechanism underlies IL-1RII expression. These findings shed light on the modulatory effects of IL1RII on Th17 responses. | en_US |
dc.description.sponsorship | National Research Foundation of Korea 2013R1A1A2012522 National Research Foundation of Korea 2018R1A2B2006310 Seoul National University Hospital 0320180220: 2018-1293 The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELIFE SCIENCES PUBLICATIONS LTD | en_US |
dc.title | Induction of the IL-1RII decoy receptor by NFAT/FOXP3 blocks IL-1β-dependent response of Th17 cells | en_US |
dc.type | Article | en_US |
dc.relation.volume | 10 | - |
dc.identifier.doi | 10.7554/eLife.61841 | en_US |
dc.relation.page | 1-29 | - |
dc.relation.journal | ELIFE | - |
dc.contributor.googleauthor | Kim, Dong Hyun | - |
dc.contributor.googleauthor | Kim, Hee Young | - |
dc.contributor.googleauthor | Cho, Sunjung | - |
dc.contributor.googleauthor | Yoo, Su-Jin | - |
dc.contributor.googleauthor | Kim, Won-Ju | - |
dc.contributor.googleauthor | Yeon, Hye Ran | - |
dc.contributor.googleauthor | Choi, Kyungho | - |
dc.contributor.googleauthor | Choi, Je-Min | - |
dc.contributor.googleauthor | Kang, Seong Wook | - |
dc.contributor.googleauthor | Lee, Won-Woo | - |
dc.relation.code | 2021007051 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | jeminchoi | - |
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