Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes
- Title
- Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes
- Author
- 권혁성
- Keywords
- Neuroinflammation; Neurodegenerative diseases; Microglia; Astrocytes
- Issue Date
- 2020-11
- Publisher
- BMC
- Citation
- TRANSLATIONAL NEURODEGENERATION, v. 9, article no. 42
- Abstract
- Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and
amyotrophic lateral sclerosis. Microglia and astrocytes are key regulators of inflammatory responses in the central
nervous system. The activation of microglia and astrocytes is heterogeneous and traditionally categorized as neurotoxic
(M1-phenotype microglia and A1-phenotype astrocytes) or neuroprotective (M2-phenotype microglia and A2-
phenotype astrocytes). However, this dichotomized classification may not reflect the various phenotypes of microglia
and astrocytes. The relationship between these activated glial cells is also very complicated, and the phenotypic
distribution can change, based on the progression of neurodegenerative diseases. A better understanding of the roles
of microglia and astrocytes in neurodegenerative diseases is essential for developing effective therapies. In this review,
we discuss the roles of inflammatory response in neurodegenerative diseases, focusing on the contributions of
microglia and astrocytes and their relationship. In addition, we discuss biomarkers to measure neuroinflammation and
studies on therapeutic drugs that can modulate neuroinflammation.
- URI
- https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-020-00221-2https://repository.hanyang.ac.kr/handle/20.500.11754/172403
- ISSN
- 2047-9158
- DOI
- 10.1186/s40035-020-00221-2
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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