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Sensitive detection of DMSO/DMF in water, human urine and blood plasma using novel 1,8-naphthalimide-based amphiphilic spectroscopic probes

Title
Sensitive detection of DMSO/DMF in water, human urine and blood plasma using novel 1,8-naphthalimide-based amphiphilic spectroscopic probes
Author
성기훈
Keywords
1,8-Naphthalimide-m-benzenesulphonamide; DMSO/DMF detection; Fluorescence quenching; Naked eye detection
Issue Date
2021-05
Publisher
ELSEVIER SCI LTD
Citation
DYES AND PIGMENTS, v. 189, Page. 1-12
Abstract
Dimethyl sulfoxide (DMSO) and dimethylformamide (DMF) are industrial toxins that need to be sensed. We synthesized 1,8-naphthalimide-m-benzenesulfonamide (NBS)-bearing probes (1?5) with different pendant chains for sensitive detection of DMSO and DMF. These probes exhibited aggregation-induced emission enhancement with increasing water concentration in ethanol. Among these, monopod probes with a single NBS unit (1?4) selectively showed large fluorescence quenching upon addition of DMSO/DMF in water. Based on this result, we prepared two water-soluble probes (8 and 9) bearing the NBS unit. These probes displayed enhanced sensitivity in detecting DMSO/DMF in water compared to probe 1, showing an extraordinary low LOD of 0.0025% for DMSO and DMF detection in water. Probe 9 was similarly effective at sensitively sensing DMSO/DMF when tap or lake water was used as the medium, and the LOD of this probe was 0.05% when biological fluids such as diluted human urine and blood plasma were used instead of water. According to DLS, FE-SEM and zeta potential studies as well as DFT calculations, disaggregation of probe aggregates and electron transfer from the photoexcited probe to DMSO/DMF are likely both responsible for the high selectivity and sensitivity of this probe in detecting the organic solvents containing a sulfoxide/amide group.
URI
https://www.sciencedirect.com/science/article/pii/S014372082100108Xhttps://repository.hanyang.ac.kr/handle/20.500.11754/171719
ISSN
0143-7208
DOI
10.1016/j.dyepig.2021.109240
Appears in Collections:
COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > BIONANO ENGINEERING(생명나노공학과) > Articles
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