Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안주홍 | - |
dc.date.accessioned | 2022-04-26T05:43:44Z | - |
dc.date.available | 2022-04-26T05:43:44Z | - |
dc.date.issued | 2020-08 | - |
dc.identifier.citation | MOLECULES AND CELLS, v. 43, no. 8, page. 671-685 | en_US |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.issn | 0219-1032 | - |
dc.identifier.uri | https://www.molcells.org/journal/view.html?doi=10.14348/molcells.2020.0060 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/170291 | - |
dc.description.abstract | The regulator of calcineurin (RCAN) was first reported as a novel gene called DSCR1, encoded in a region termed the Down syndrome critical region (DSCR) of human chromosome 21. Genome sequence comparisons across species using bioinformatics revealed three members of the RCAN gene family, RCAN1, RCAN2, and RCAN3, present in most jawed vertebrates, with one member observed in most invertebrates and fungi. RCAN is most highly expressed in brain and striated muscles, but expression has been reported in many other tissues, as well, including the heart and kidneys. Expression levels of RCAN homologs are responsive to external stressors such as reactive oxygen species, Ca2+, amyloid beta, and hormonal changes and upregulated in pathological conditions, including Alzheimer's disease, cardiac hypertrophy, diabetes, and degenerative neuropathy. RCAN binding to calcineurin, a Ca2+/calmodulin-dependent phosphatase, inhibits calcineurin activity, thereby regulating different physiological events via dephosphorylation of important substrates. Novel functions of RCANs have recently emerged, indicating involvement in mitochondria homeostasis, RNA binding, circadian rhythms, obesity, and thermogenesis, some of which are calcineurin-independent. These developments suggest that besides significant contributions to DS pathologies and calcineurin regulation, RCAN is an important participant across physiological systems, suggesting it as a favorable therapeutic target. | en_US |
dc.description.sponsorship | This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology (2018R1A2A3074987 to S.K.L.; 2018R1D-1A1B07046893 to IA.). We sincerely apologize to our colleagues in case we unwittingly omit their valuable works in this review. | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | en_US |
dc.subject | calcineurin | en_US |
dc.subject | Down syndrome | en_US |
dc.subject | RCAN1 | en_US |
dc.subject | RCAN2 | en_US |
dc.subject | RCAN3 | en_US |
dc.title | Regulator of Calcineurin (RCAN): Beyond Down Syndrome Critical Region | en_US |
dc.type | Article | en_US |
dc.relation.no | 8 | - |
dc.relation.volume | 43 | - |
dc.identifier.doi | 10.14348/molcells.2020.0060 | - |
dc.relation.page | 671-685 | - |
dc.relation.journal | MOLECULES AND CELLS | - |
dc.contributor.googleauthor | Lee, Sun-Kyung | - |
dc.contributor.googleauthor | Ahnn, Joohong | - |
dc.relation.code | 2020053400 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | joohong | - |
dc.identifier.orcid | https://orcid.org/0000-0003-2229-3580 | - |
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