Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이종민 | - |
dc.date.accessioned | 2022-04-15T04:58:14Z | - |
dc.date.available | 2022-04-15T04:58:14Z | - |
dc.date.issued | 2020-08 | - |
dc.identifier.citation | JOURNAL OF CLINICAL MEDICINE, v. 9, no. 8, article no. 2663 | en_US |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://www.mdpi.com/2077-0383/9/8/2663 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/170024 | - |
dc.description.abstract | White matter hyperintensity (WMH) has been recognised as a surrogate marker of small vessel disease and is associated with cognitive impairment. We investigated the dynamic change in WMH in patients with severe WMH at baseline, and the effects of longitudinal change of WMH volume on cognitive decline and cortical thinning. Eighty-seven patients with subcortical vascular mild cognitive impairment were prospectively recruited from a single referral centre. All of the patients were followed up with annual neuropsychological tests and 3T brain magnetic resonance imaging. The WMH volume was quantified using an automated method and the cortical thickness was measured using surface-based methods. Participants were classified into WMH progression and WMH regression groups based on the delta WMH volume between the baseline and the last follow-up. To investigate the effects of longitudinal change in WMH volume on cognitive decline and cortical thinning, a linear mixed effects model was used. Seventy patients showed WMH progression and 17 showed WMH regression over a three-year period. The WMH progression group showed more rapid cortical thinning in widespread regions compared with the WMH regression group. However, the rate of cognitive decline in language, visuospatial function, memory and executive function, and general cognitive function was not different between the two groups. The results of this study indicated that WMH volume changes are dynamic and WMH progression is associated with more rapid cortical thinning. | en_US |
dc.description.sponsorship | This research was supported by a National Research Foundation (NRF) of Korea grant funded by the Korea government (MSIP; NRF-2018R1A1A3A04079255); the Korean Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (HI18C0335, HI18C1629); the MSIT (Ministry of Science and ICT), Korea, under the ICT Creative Consilience program (IITP-2020-0-01821) supervised by the IITP (Institute for Information & communications Technology Planning & Evaluation); and a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (HI19C1132). | en_US |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.subject | white matter hyperintensity | en_US |
dc.subject | cortical thinning | en_US |
dc.subject | cognitive decline | en_US |
dc.subject | subcortical vascular mild cognitive impairment | en_US |
dc.title | The Effects of Longitudinal White Matter Hyperintensity Change on Cognitive Decline and Cortical Thinning over Three Years | en_US |
dc.type | Article | en_US |
dc.relation.no | 8 | - |
dc.relation.volume | 9 | - |
dc.identifier.doi | 10.3390/jcm9082663 | - |
dc.relation.page | 1-12 | - |
dc.relation.journal | JOURNAL OF CLINICAL MEDICINE | - |
dc.contributor.googleauthor | Kim, Seung Joo | - |
dc.contributor.googleauthor | Lee, Dong Kyun | - |
dc.contributor.googleauthor | Jang, Young Kyoung | - |
dc.contributor.googleauthor | Jang, Hyemin | - |
dc.contributor.googleauthor | Kim, Si Eun | - |
dc.contributor.googleauthor | Cho, Soo Hyun | - |
dc.contributor.googleauthor | Kim, Jun Pyo | - |
dc.contributor.googleauthor | Jung, Young Hee | - |
dc.contributor.googleauthor | Kim, Eun-Joo | - |
dc.contributor.googleauthor | Lee, Jong-Min | - |
dc.relation.code | 2020047025 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | SCHOOL OF ELECTRICAL AND BIOMEDICAL ENGINEERING | - |
dc.identifier.pid | ljm | - |
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