Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 문효방 | - |
dc.date.accessioned | 2022-03-08T05:32:58Z | - |
dc.date.available | 2022-03-08T05:32:58Z | - |
dc.date.issued | 2021-08 | - |
dc.identifier.citation | JOURNAL OF HAZARDOUS MATERIALS, v. 416, Page. 125956-125956 | en_US |
dc.identifier.issn | 0304-3894 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0304389421009201?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/168934 | - |
dc.description.abstract | Exposure to a single organochlorine pesticide (OCP) at high concentration and over a short period of exposure constrain our understanding of the contribution of chemical exposure to type 2 diabetes (T2D). A total of 450 male and female zebrafish was exposed to mixtures of five OCPs at 0, 0.05, 0.25, 2.5, and 25 mu g/L for 12 weeks. T2D-related hematological parameters (i.e., glucose, insulin, free fatty acid, and triglycerides) and mitochondrial complex I to IV activities were assessed. Metabolomics, proteomics, and transcriptomics were analyzed in female livers, and their data-driven integration was performed. High fasting glucose and low insulin levels were observed only at 0.05 mu g/L of the OCP mixture in females, indicating a nonlinear and sexually dependent response. We found that exposure to the OCP mixture inhibited the activities of mitochondrial complexes, especially III and IV. Combining individual and integrated omics analysis, T2D-linked metabolic pathways that regulate mitochondrial function, insulin signaling, and energy homeostasis were altered by the OCP mixture, which explains the observed phenotypic hematological effects. We demonstrated the cause-and-effect relationship between exposures to OCP mixture and T2D using zebrafish model. This study gives an insight into mechanistic research of metabolic diseases caused by chemical exposure using zebrafish. | en_US |
dc.description.sponsorship | This study was supported by Korea Ministry of Environment (MOE) as the Environmental Health Action Program (2016001370001). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER | en_US |
dc.subject | Organochlorine pesticide mixtures | en_US |
dc.subject | Type 2 diabetes | en_US |
dc.subject | Zebrafish | en_US |
dc.subject | Multi-omics | en_US |
dc.title | Nonmonotonic response of type 2 diabetes by low concentration organochlorine pesticide mixture: Findings from multi-omics in zebrafish | en_US |
dc.type | Article | en_US |
dc.relation.volume | 416 | - |
dc.identifier.doi | 10.1016/j.jhazmat.2021.125956 | - |
dc.relation.page | 125956-125956 | - |
dc.relation.journal | JOURNAL OF HAZARDOUS MATERIALS | - |
dc.contributor.googleauthor | Lee, Hyojin | - |
dc.contributor.googleauthor | Gao, Yan | - |
dc.contributor.googleauthor | Ko, Eun | - |
dc.contributor.googleauthor | Lee, Jihye | - |
dc.contributor.googleauthor | Lee, Hyun-Kyung | - |
dc.contributor.googleauthor | Lee, Sangkyu | - |
dc.contributor.googleauthor | Choi, Moonsung | - |
dc.contributor.googleauthor | Shin, Sooim | - |
dc.contributor.googleauthor | Park, Youngja Hwang | - |
dc.contributor.googleauthor | Moon, Hyo-Bang | - |
dc.contributor.googleauthor | Uppal, Karan | - |
dc.contributor.googleauthor | Kim, Ki-Tae | - |
dc.relation.code | 2021000701 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E] | - |
dc.sector.department | DEPARTMENT OF MARINE SCIENCE AND CONVERGENCE ENGINEERING | - |
dc.identifier.pid | hbmoon | - |
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