Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 조용우 | - |
dc.date.accessioned | 2022-03-08T05:30:24Z | - |
dc.date.available | 2022-03-08T05:30:24Z | - |
dc.date.issued | 2021-08 | - |
dc.identifier.citation | JOURNAL OF CONTROLLED RELEASE, v. 336, Page. 285-295 | en_US |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0168365921003187 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/168930 | - |
dc.description.abstract | Allogeneic transplantation of mesenchymal stem cell-derived extracellular vesicles (EVs) offers great potential for treating liver fibrosis. However, owing to their intrinsic surface characteristics, bare EVs are non-specifically distributed in the liver tissue after systemic administration, leading to limited therapeutic efficacy. To target activated hepatic stellate cells (HSCs), which are responsible for hepatic fibrogenesis, vitamin A-coupled small EVs (V-EVs) were prepared by incorporating vitamin A derivative into the membrane of bare EVs. No significant differences were found in the particle size and morphology between bare and V-EVs. In addition, surface engineering of EVs did not affect the expression of surface marker proteins (e.g., CD63 and CD9), as demonstrated by flow cytometry. Owing to the surface incorporation of vitamin A, V-EVs were selectively taken up by activated HSCs via receptor-mediated endocytosis. When systemically administered to mice with liver fibrosis, V-EVs effectively targeted activated HSCs in the liver tissue, resulting in reversal of the fibrotic cascade. Consequently, even at a 10-fold lower dose, V-EVs exhibited comparable anti-fibrotic effects to those of bare EVs, substantiating their therapeutic potential for liver fibrosis. | en_US |
dc.description.sponsorship | This work was supported by Korea Health Technology R&D Project (HI20C0437) of the Ministry of Health & Welfare and Basic Science Research Program (2018R1A2B3006080) of the National Research Foundation (NRF), Republic of Korea. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER | en_US |
dc.subject | Extracellular vesicles | en_US |
dc.subject | Surface engineering | en_US |
dc.subject | Targeted delivery | en_US |
dc.subject | Hepatic stellate cells | en_US |
dc.subject | Liver fibrosis | en_US |
dc.title | Vitamin A-coupled stem cell-derived extracellular vesicles regulate the fibrotic cascade by targeting activated hepatic stellate cells in vivo | en_US |
dc.type | Article | en_US |
dc.relation.volume | 336 | - |
dc.identifier.doi | 10.1016/j.jconrel.2021.06.031 | - |
dc.relation.page | 285-295 | - |
dc.relation.journal | JOURNAL OF CONTROLLED RELEASE | - |
dc.contributor.googleauthor | You, Dong Gil | - |
dc.contributor.googleauthor | Oh, Byeong Hoon | - |
dc.contributor.googleauthor | Nguyen, Van Quy | - |
dc.contributor.googleauthor | Lim, Gyeong Taek | - |
dc.contributor.googleauthor | Um, Wooram | - |
dc.contributor.googleauthor | Jung, Jae Min | - |
dc.contributor.googleauthor | Jeon, Jueun | - |
dc.contributor.googleauthor | Choi, Ji Suk | - |
dc.contributor.googleauthor | Choi, Young Chan | - |
dc.contributor.googleauthor | Jung, Youn Jae | - |
dc.contributor.googleauthor | Lee, Jungmi | - |
dc.contributor.googleauthor | Jo, Dong-Gyu | - |
dc.contributor.googleauthor | Cho, Yong Woo | - |
dc.contributor.googleauthor | Park, Jae Hyung | - |
dc.relation.code | 2021004235 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF ENGINEERING SCIENCES[E] | - |
dc.sector.department | DEPARTMENT OF MATERIALS SCIENCE AND CHEMICAL ENGINEERING | - |
dc.identifier.pid | ywcho7 | - |
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