Effect of daily tadalafil on reported outcomes in patients with erectile dysfunction and depressive symptoms STROBE, a case-control study
- Title
- Effect of daily tadalafil on reported outcomes in patients with erectile dysfunction and depressive symptoms STROBE, a case-control study
- Author
- 문홍상
- Keywords
- depression; erectile dysfunction; phosphodiesterase 5 inhibitors
- Issue Date
- 2020-06
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Citation
- MEDICINE, v. 99, no. 23, article no. e20546
- Abstract
- Erectile dysfunction (ED) and depression are closely related. We sought to determine ED and depression were improved by tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor, at 5mg daily, in this case-control study. Participants were men aged 20 to 65 years with ED for ˃3 months, International Index of Erectile Function-5 (IIEF) score ˂21 points, and Zung Self-Rating Depression Scale (SDS) survey result ˃50 points who were willing to participate.
On first visit (V1) and after 1 (V2) and 2 months (V3), clinical features were examined using IIEF-5 for diagnosing and evaluating ED, SDS for evaluating depression, and International Prostate Symptom Score and Quality of Life (IPSS/QoL) survey for examining lower urinary tract symptoms (LUTS). Tadalafil 5mg was administered daily for 2 months.
A total of 60 participants were an average age of 58.68 +/- 6.71 years. Patient overall average IIEF was 8.76 +/- 5.98, showing mild ED symptoms, and total average IPSS 13.74 +/- 7.55 showed moderate LUTS. Average overall SDS index was 58.93 +/- 9.21, indicating moderate-to-severe findings. Average change in IIEF among all patients revealed significant improvement from V1 to V2 (-2.69 +/- 1.22, P=.03) and V1 to V3 (-4.38 +/- 1.20, P˂ 0.01). IPSS also significantly improved from V1 to V3 (3.48 +/- 1.37, P=.01), as did SDS index (V1, V2: 4.69 +/- 1.89, P= 0.02), (V1, V3: 5.43 +/- 1.89, P˂.01). Patients with severe IIEF scores (group 1, n= 27) experienced significantly greater improvement in IIEF from V1 to V2 and V1 and V3, compared to those with mild-to-moderate IIEF scores. Both groups improved in SDS index from V1 to V2 and V1 to V3, with the greatest improvement between V1 and V3 for group 1 and V1 and V2 for group 2.
Daily tadalafil 5 mg could be helpful for ED patients with depressive symptoms and improved LUTS and quality of life.
- URI
- https://journals.lww.com/md-journal/Fulltext/2020/06050/Effect_of_daily_tadalafil_on_reported_outcomes_in.55.aspxhttps://repository.hanyang.ac.kr/handle/20.500.11754/167395
- ISSN
- 0025-7974; 1536-5964
- DOI
- 10.1097/MD.0000000000020546
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML