Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상수 | - |
dc.date.accessioned | 2021-10-29T02:42:12Z | - |
dc.date.available | 2021-10-29T02:42:12Z | - |
dc.date.issued | 2020-04 | - |
dc.identifier.citation | SMALL, v. 16, no. 16, article no. 2000012 | en_US |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.issn | 1613-6829 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/10.1002/smll.202000012 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/166045 | - |
dc.description.abstract | Atherosclerosis development leads to irreversible cascades, highlighting the unmet need for improved methods of early diagnosis and prevention. Disturbed flow formation is one of the earliest atherogenic events, resulting in increased endothelial permeability and subsequent monocyte recruitment. Here, a mesenchymal stem cell (MSC)-derived nanovesicle (NV) that can target disturbed flow sites with the peptide GSPREYTSYMPH (PREY) (PMSC-NVs) is presented which is selected through phage display screening of a hundred million peptides. The PMSC-NVs are effectively produced from human MSCs (hMSCs) using plasmid DNA designed to functionalize the cell membrane with PREY. The potent anti-inflammatory and pro-endothelial recovery effects are confirmed, similar to those of hMSCs, employing mouse and porcine partial carotid artery ligation models as well as a microfluidic disturbed flow model with human carotid artery-derived endothelial cells. This nanoscale platform is expected to contribute to the development of new theragnostic strategies for preventing the progression of atherosclerosis. | en_US |
dc.description.sponsorship | J.-K.Y., D.-H.K., and M.-L.K. contributed equally to this work. This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning (NRF-2016M3A9E9941743; H.J.S.), Ministry of Education (NRF-2018R1A6A3A01012997; J.K.Y.), the American Heart Association Scientist Development Grant 15SDG25080314 (Y.K.), and the National Institutes of Health Director's New Innovator Award 1DP2HL142050 (Y.K.). This work was partially performed at the core facilities at the Parker H. Petit Institute for Bioengineering and Bioscience at the Georgia Institute of Technology and the Institute for Electronics and Nanotechnology at the Georgia Institute of Technology, a member of the National Nanotechnology Coordinated Infrastructure, which is supported by the National Science Foundation (Grant ECCS1542174). | en_US |
dc.language.iso | en | en_US |
dc.publisher | WILEY-V C H VERLAG GMBH | en_US |
dc.subject | atherosclerosis | en_US |
dc.subject | disturbed blood flow | en_US |
dc.subject | mesenchymal stem cells | en_US |
dc.subject | nanovesicles | en_US |
dc.subject | plasmid design | en_US |
dc.title | Anti-Atherogenic Effect of Stem Cell Nanovesicles Targeting Disturbed Flow Sites | en_US |
dc.type | Article | en_US |
dc.relation.no | 16 | - |
dc.relation.volume | 16 | - |
dc.identifier.doi | 10.1002/smll.202000012 | - |
dc.relation.page | 1-14 | - |
dc.relation.journal | SMALL | - |
dc.contributor.googleauthor | Yoon, Jeong-Kee | - |
dc.contributor.googleauthor | Kim, Dae-Hyun | - |
dc.contributor.googleauthor | Kang, Mi-Lan | - |
dc.contributor.googleauthor | Jang, Hyeon-Ki | - |
dc.contributor.googleauthor | Park, Hyun-Ji | - |
dc.contributor.googleauthor | Lee, Jung Bok | - |
dc.contributor.googleauthor | Yi, Se Won | - |
dc.contributor.googleauthor | Kim, Hye-Seon | - |
dc.contributor.googleauthor | Baek, Sewoom | - |
dc.contributor.googleauthor | Bae, Sangsu | - |
dc.relation.code | 2020047591 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF CHEMISTRY | - |
dc.identifier.pid | sangsubae | - |
dc.identifier.researcherID | E-5324-2017 | - |
dc.identifier.orcid | https://orcid.org/0000-0003-3615-8566 | - |
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