Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최한곤 | - |
dc.date.accessioned | 2021-10-29T01:51:29Z | - |
dc.date.available | 2021-10-29T01:51:29Z | - |
dc.date.issued | 2009-08 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v. 72, no. 3, page. 539-545 | en_US |
dc.identifier.issn | 0939-6411 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0939641109000782 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/166001 | - |
dc.description.abstract | The main objective of this study was to prepare a solid form of lipid-based self-emulsifying drug delivery system (SEDDS) by spray drying liquid SEDDS with an inert solid carrier Aerosil 200 to improve the oral bioavailability of poorly water-soluble drug dexibuprofen. The liquid SEDDS was a system that consisted of dexibuprofen, Labrasol, Capryol 90 and Labrafil M 1944 CS. The particle size analysis revealed no difference in the z-average particle diameter of the reconstituted emulsion between liquid and solid SEDDS. The solid SEDDS was characterized by SEM, DSC and XRD studies. In vivo results of solid SEDDS and dexibuprofen powder in rats at the dose of 10 mg/kg showed that the initial plasma concentrations of drug in solid SEDDS were significantly higher than those of dexibuprofen powder (P < 0.05). The solid SEDDS gave significantly higher AUC and Cmax than did dexibuprofen powder (P < 0.05). In particular, the AUC of solid SEDDS was about twofold higher than that of dexibuprofen powder. Our results suggested that this solid SEDDS could be used as an effective oral solid dosage form to improve the bioavailability of poorly water-soluble drug dexibuprofen. | en_US |
dc.description.sponsorship | This research was supported by the Grant No. RTI04-01-04 from the Regional Technology Innovation Program of the Ministry of Knowledge Economy (MKE) and was financially supported by the Ministry of Science and Technology (M10414030001-05N1403-00140) in South Korea. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.subject | Poorly water-soluble drugs | en_US |
dc.subject | Self-emulsifying systems | en_US |
dc.subject | Spray drying | en_US |
dc.subject | Solid dosage form | en_US |
dc.subject | Bioavailability | en_US |
dc.title | Enhanced oral bioavailability of dexibuprofen by a novel solid Self-emulsifying drug delivery system (SEDDS) | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 72 | - |
dc.identifier.doi | 10.1016/j.ejpb.2009.03.001 | - |
dc.relation.page | 539-545 | - |
dc.relation.journal | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | - |
dc.contributor.googleauthor | Balakrishnan, Prabagar | - |
dc.contributor.googleauthor | Lee, Beom-Jin | - |
dc.contributor.googleauthor | Oh, Dong Hoon | - |
dc.contributor.googleauthor | Kim, Jong Oh | - |
dc.contributor.googleauthor | Hong, Myung Ja | - |
dc.contributor.googleauthor | Jee, Jun-Pil | - |
dc.contributor.googleauthor | Kim, Jung Ae | - |
dc.contributor.googleauthor | Yoo, Bong Kyu | - |
dc.contributor.googleauthor | Woo, Jong Soo | - |
dc.contributor.googleauthor | Choi, Han-Gon | - |
dc.relation.code | 2009212687 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | hangon | - |
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