Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최성용 | - |
dc.date.accessioned | 2021-10-28T07:26:43Z | - |
dc.date.available | 2021-10-28T07:26:43Z | - |
dc.date.issued | 2020-04 | - |
dc.identifier.citation | JOURNAL OF CONTROLLED RELEASE, v. 322, page. 337-345 | en_US |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.issn | 1873-4995 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S016836592030198X?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/165934 | - |
dc.description.abstract | Nuclear medicine is a routine but essential clinical option for diagnostic imaging and disease treatment. Encapsulating radioisotopes in injectable biodegradable hydrogels is ideal for localizing radiation sources to target tissues or organs to achieve long-term, low-dose radiotherapy. However, difficulties in the on-site production of radioactive gels upon treatment and the unpredictable radiation level at the target region are major obstacles to their clinical use. In this study, we bypassed these limitations by developing locally injectable hydrogel microparticles based on I-131-labeled photo-crosslinkable hyaluronic acid (HA) and a microfluidic highthroughput droplet generator. This approach enabled rapid on-site production of injectable, radioactive, biodegradable (IRB) HA microgels, thus allowing their immediate therapeutic application with improved local retention and predictable radioactivity. We demonstrated the clinical utility of this comprehensive approach by preparing IRB HA microgels within 15 min and localizing them to the target tissue (rat muscle) with minimal offtarget biodistribution and in vivo radioactivity that extended beyond 3 weeks. | en_US |
dc.description.sponsorship | This research was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF2018R1A4A1025623), and by the National Creative Research Initiative Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF2017R1D1A3B03035360). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER | en_US |
dc.subject | Injectable drug delivery system | en_US |
dc.subject | Radiotherapy | en_US |
dc.subject | Hyaluronic acid | en_US |
dc.subject | 131I | en_US |
dc.subject | Hydrogel microparticle | en_US |
dc.title | On-site fabrication of injectable I-131-labeled microgels for local radiotherapy | en_US |
dc.type | Article | en_US |
dc.relation.volume | 322 | - |
dc.identifier.doi | 10.1016/j.jconrel.2020.03.046 | - |
dc.relation.page | 337-345 | - |
dc.relation.journal | JOURNAL OF CONTROLLED RELEASE | - |
dc.contributor.googleauthor | Kim, Sodam | - |
dc.contributor.googleauthor | Yim, Sang-Gu | - |
dc.contributor.googleauthor | Chandrasekharan, Ajeesh | - |
dc.contributor.googleauthor | Seong, Keum-Yong | - |
dc.contributor.googleauthor | Lee, Tae Wook | - |
dc.contributor.googleauthor | Kim, Byeongyeon | - |
dc.contributor.googleauthor | Kim, Keunyoung | - |
dc.contributor.googleauthor | Choi, Sungyoung | - |
dc.contributor.googleauthor | Yang, Seung Yun | - |
dc.relation.code | 2020051626 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | SCHOOL OF ELECTRICAL AND BIOMEDICAL ENGINEERING | - |
dc.identifier.pid | sungyoung | - |
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