Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이준석 | - |
dc.date.accessioned | 2021-10-22T07:06:28Z | - |
dc.date.available | 2021-10-22T07:06:28Z | - |
dc.date.issued | 2020-02 | - |
dc.identifier.citation | ADVANCED FUNCTIONAL MATERIALS, v. 30, no. 15, article no. 1910475 | en_US |
dc.identifier.issn | 1616-301X | - |
dc.identifier.issn | 1616-3028 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/10.1002/adfm.201910475 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/165655 | - |
dc.description.abstract | Abnormal accumulation of β-amyloid (Aβ) peptide aggregates in the brain is a major hallmark of Alzheimer's disease (AD). Aβ aggregates interfere with neuronal communications, ultimately causing neuronal damage and brain atrophy. Much effort has been made to develop AD treatments that suppress Aβ aggregate formation, thereby attenuating Aβ-induced neurotoxicity. Here, the design of Aβ nanodepletors consisting of ultralarge mesoporous silica nanostructures and anti-Aβ single-chain variable fragments, with the goal of targeting and eliminating aggregative Aβ monomers, is reported. The Aβ nanodepletors impart a notable decline in Aβ aggregate formation, resulting in significant mitigation of Aβ-induced neurotoxicity in vitro. Furthermore, stereotaxic injections of Aβ nanodepletors into the brain of an AD mouse model system successfully suppress Aβ plaque formation in vivo up to ≈30%, suggesting that Aβ nanodepletors can serve as a promising antiamylodoisis material. | en_US |
dc.description.sponsorship | H.J., Y.J.C., R.W., and C.H.L. contributed equally to this work. This study was supported by grants from the Korea Institute of Science and Technology Institutional Program (No. 2E26990/CAP-16-02-KIST) and the National Research Foundation via the Creative Research Initiative Center (Grant No. NRF-2015R1A3A2066191) and Basic Science Research Program (Grant No. NRF-2017R1D1A1B03033124 to H.K.), Republic of Korea. Use of the Center for Nanoscale Materials, an Office of Science user facility, was supported by the U. S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357. J.L. acknowledges the Director's Postdoctoral Fellowship from Argonne National Laboratory. The authors thank Sol Lee at Gwangju Center, Korea Basic Science Institute (KBSI) for helpful discussions on preparation of tissue extracts and biological analyses. | en_US |
dc.language.iso | en | en_US |
dc.publisher | WILEY-V C H VERLAG GMBH | en_US |
dc.subject | β-amyloid peptides | en_US |
dc.subject | Alzheimer's disease | en_US |
dc.subject | nanodepletors | en_US |
dc.subject | scFv | en_US |
dc.subject | silica nanostructures | en_US |
dc.title | Silica Nanodepletors: Targeting and Clearing Alzheimer's β‐Amyloid Plaques | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1002/adfm.201910475 | - |
dc.relation.journal | ADVANCED FUNCTIONAL MATERIALS | - |
dc.contributor.googleauthor | Jung, Huijin | - |
dc.contributor.googleauthor | Chung, You Jung | - |
dc.contributor.googleauthor | Wilton, Rosemarie | - |
dc.contributor.googleauthor | Lee, Chang Heon | - |
dc.contributor.googleauthor | Lee, Byung Il | - |
dc.contributor.googleauthor | Lim, Jinyeong | - |
dc.contributor.googleauthor | Lee, Hyojin | - |
dc.contributor.googleauthor | Choi, Jong-Ho | - |
dc.contributor.googleauthor | Kang, Hyuno | - |
dc.contributor.googleauthor | Lee, Joonseok | - |
dc.relation.code | 2020049013 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF CHEMISTRY | - |
dc.identifier.pid | joonseoklee | - |
dc.identifier.researcherID | AAP-6003-2021 | - |
dc.identifier.orcid | https://orcid.org/0000-0001-9551-6402 | - |
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