Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김진기 | - |
dc.date.accessioned | 2021-07-28T06:48:48Z | - |
dc.date.available | 2021-07-28T06:48:48Z | - |
dc.date.issued | 2020-06 | - |
dc.identifier.citation | COLLOIDS AND SURFACES B-BIOINTERFACES, v. 194, Article no. 111209, 10pp | en_US |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0927776520305658 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/163400 | - |
dc.description.abstract | The potential of duloxetine-loaded solid lipid nanoparticles (DLX-SLNs) for enhanced antidepressant activity was investigated in the current study. Nano-template engineering technology was successfully employed for the preparation of DLX-SLNs. In vivo forced swim and tail suspension tests were used to evaluate behavioral changes of rats in lipopolysaccharide-induced depression. The determination of brain-derived neurotropic factor (BDNF) in brain and plasma was carried out using enzyme-linked immunosorbent assay. The incorporation efficiency of optimized DLX-SLNs formulation was found to be 80 % with particle size of 114.5 nm, PDI of 0.29 and zeta potential of-18.2 mV. Powder X-ray diffractometry and differential scanning calorimetry demonstrated sufficient incorporation into lipid matrix and amorphous behavior of DLX. In vitro release profile of DLX-SLNs showed a sustained release achieving a cumulative amount of 52.97 % for 24 h. DLX-SLNs showed a significant decrease in immobility time in forced swim and tail suspension tests. DLX-SLNs increased BDNF levels in plasma and brain after 2 weeks. Immunohistochemistry results demonstrated significant reduction in the expression of tumor necrosis factor-alpha and cyclooxygenase enzyme-2 in brain. In conclusion, solid lipid nanoparticles can be utilized as a potential carrier for the delivery of antidepressant drugs into the brain. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER | en_US |
dc.subject | Duloxetine | en_US |
dc.subject | Antidepressant activity | en_US |
dc.subject | Solid lipid nanoparticles | en_US |
dc.subject | Lipopolysaccharide-induced depression | en_US |
dc.subject | Brain-derived neurotropic factor | en_US |
dc.title | Solid lipid nanoparticles-mediated enhanced antidepressant activity of duloxetine in lipopolysaccharide-induced depressive model | en_US |
dc.type | Article | en_US |
dc.relation.volume | 194 | - |
dc.identifier.doi | 10.1016/j.colsurfb.2020.111209 | - |
dc.relation.page | 111209-111218 | - |
dc.relation.journal | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.contributor.googleauthor | Rana, Isra | - |
dc.contributor.googleauthor | Khan, Namrah | - |
dc.contributor.googleauthor | Ansari, Muhammad Mohsin | - |
dc.contributor.googleauthor | Shah, Fawad Ali | - |
dc.contributor.googleauthor | Din, Fakhar ud | - |
dc.contributor.googleauthor | Sarwar, Sadia | - |
dc.contributor.googleauthor | Imran, Muhammad | - |
dc.contributor.googleauthor | Qureshi, Omer Salman | - |
dc.contributor.googleauthor | Choi, Ho-Ik | - |
dc.contributor.googleauthor | Lee, Cheol-Ho | - |
dc.contributor.googleauthor | Zeb, Alam | - |
dc.contributor.googleauthor | Kim, Jin-Ki | - |
dc.relation.code | 2020046123 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | jinkikim | - |
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