Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정지은 | - |
dc.date.accessioned | 2021-07-27T01:50:45Z | - |
dc.date.available | 2021-07-27T01:50:45Z | - |
dc.date.issued | 2020-02 | - |
dc.identifier.citation | JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, v. 21, no. 2, page. 201-211 | en_US |
dc.identifier.issn | 1525-8610 | - |
dc.identifier.uri | https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S1525861019306334?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1525861019306334%3Fshowall%3Dtrue&referrer=https:%2F%2Fwww.scopus.com%2Frecord%2Fdisplay.uri%3Feid%3D2-s2.0-85074512114%26origin%3Dinward%26txGid%3Dd8771c9c5150e72edf75094b81a7d09f | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/163191 | - |
dc.description.abstract | Objective: To examine the association between benzodiazepine use and the risk of dementia. Design, setting, and participants: We conducted a retrospective cohort study, using a nationwide healthcare database of South Korea (2002-2016). The participants included new users of benzodiazepines aged ˃= 50 years, with no prior prescription record of benzodiazepines or a history of dementia within the previous 5 years (2002-2006). Methods: Outcome was defined as an incident dementia with specified algorithms using diagnosis and prescription records, with the application of a 5-year lag-time following the index date during which outcomes were censored. We used a multivariable Cox proportional hazard model to estimate hazard ratio (HR) and the 95% confidence interval (CI). Comorbidities and comedications were treated as time-varying covariates in 90-day windows, and an active comparator was used to reduce potential bias from confounding by indication. Active comparators were defined as new-users of antidepressants. Results: Our final participants included 616,256 patients, after propensity score estimation and matching on a 1:1 ratio. We observed a 23% increase in the risk of dementia in benzodiazepine users, compared with that in nonusers, over a mean follow-up period of 5.5 years (HR 1.23, 95% CI 1.14-1.32). A consistent finding was observed when the lag-time duration was extended to 7 years, revealing a close to association (HR 1.17, 95% CI 1.04-1.30). When new-users of antidepressants were used as the active comparator, no increase in the risk of dementia with benzodiazepines was observed over 7 years (HR 1.01, 95% CI 0.81-1.27). Conclusions and implications: A significant association was observed between benzodiazepine use and the risk of dementia, compared with nonusers. However, a or negative association was observed with the use of the active comparator, suggesting the absence of a causal association between dementia and benzodiazepine use. (C) 2019 AMDA - The Society for Post-Acute and Long-Term Care Medicine. | en_US |
dc.description.sponsorship | We sincerely thank National Health Insurance Service for their cooperation in providing access to the database (Data number: NHIS-2018-1-071). Lisa Kalisch Ellett is supported by an NHMRC-ARC Dementia Research Development Fellowship (Grant identification number APP1101788). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCIENCE INC | en_US |
dc.subject | Dementia | en_US |
dc.subject | benzodiazepine | en_US |
dc.subject | cohort studies | en_US |
dc.subject | propensity score | en_US |
dc.title | Uncertain Association Between Benzodiazepine Use and the Risk of Dementia: A Cohort Study | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 21 | - |
dc.identifier.doi | 10.1016/j.jamda.2019.08.017 | - |
dc.relation.page | 201-201 | - |
dc.relation.journal | JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION | - |
dc.contributor.googleauthor | Baek, Yeon-Hee | - |
dc.contributor.googleauthor | Lee, Hyesung | - |
dc.contributor.googleauthor | Kim, Woo Jung | - |
dc.contributor.googleauthor | Chung, Jee-Eun | - |
dc.contributor.googleauthor | Pratt, Nicole | - |
dc.contributor.googleauthor | Kalisch Ellett, Lisa | - |
dc.contributor.googleauthor | Shin, Ju-Young | - |
dc.relation.code | 2020054495 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | jechung | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.