Clinical Implication of Altered Inhibitory Response in Patients with Post-traumatic Stress Disorder: Electrophysiological Evidence from a Go/Nogo Task
- Title
- Clinical Implication of Altered Inhibitory Response in Patients with Post-traumatic Stress Disorder: Electrophysiological Evidence from a Go/Nogo Task
- Author
- 김성권
- Keywords
- PTSD; Go/Nogo; N2 latency; Cortical volume
- Issue Date
- 2020-03
- Publisher
- SPRINGER
- Citation
- BRAIN TOPOGRAPHY, v. 33, no. 2, page. 208-220
- Abstract
- Inhibitory dysfunction is closely associated to post-traumatic stress disorder (PTSD). The present study investigated the
neurophysiological evidence for and the brain regions related to inhibitory dysfunction in PTSD. Fifty patients with PTSD
and 63 healthy controls (HCs) participated in a Go/Nogo task combined with electroencephalographic recordings. The
N2–P3 complexes of event-related potentials (ERPs) elicited during the Nogo condition were compared between groups.
Participants underwent structural magnetic resonance imaging to examine cortical volumes and completed questionnaires.
Correlations between altered ERPs and cortical volumes of regions of interest as well as psychological symptoms were
analysed. Nogo-N2 latencies at fve electrode sites (Fz, FCz, Cz, CPz, and Pz) were signifcantly delayed in patients with
PTSD compared to HCs. Nogo-N2 latency had a signifcant negative correlation with the volume of gyrus in the inferior
frontal cortex, orbitofrontal cortex, amygdala, and medial prefrontal cortex. Nogo-N2 latency was signifcantly and positively
correlated with catastrophizing, anxiety, and perceived threat. These fndings show inhibitory dysfunction in patients with
PTSD, refected by the delay in Nogo-N2 latencies. They also indicate that Nogo-N2 latencies are associated with smaller
cortical volumes responsible for inhibition as well as with major symptoms of PTSD.
- URI
- https://www.proquest.com/docview/2376093699?accountid=11283https://repository.hanyang.ac.kr/handle/20.500.11754/163122
- ISSN
- 1573-6792; 0896-0267
- DOI
- 10.1007/s10548-020-00754-9
- Appears in Collections:
- ETC[S] > 연구정보
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