Association between insulin resistance and risk of atrial fibrillation in non-diabetics
- Title
- Association between insulin resistance and risk of atrial fibrillation in non-diabetics
- Author
- 이용구
- Keywords
- Insulin resistance; atrial fibrillation; obesity; epidemiology
- Issue Date
- 2020-03
- Publisher
- SAGE PUBLICATIONS LTD
- Citation
- EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, v. 27, no. 18, page. 1934-1941
- Abstract
- Aims: Previous studies from Western countries have been unable to demonstrate a relationship between insulin resistance and new-onset atrial fibrillation. We aimed to evaluate this relationship in the nondiabetic Asian population.
Methods: Between 2001-2003, 8175 adults (mean age 51.5 years, 53% women) without both existing atrial fibrillation and diabetes and with insulin resistance measures at baseline were enrolled and were followed by biennial electrocardiograms thereafter until 2014. We constructed multivariable-adjusted Cox proportional hazard models for risk of incident atrial fibrillation.
Results: Over a median follow-up of 12.3 years, 136 participants (1.89/1000 person-years) developed atrial fibrillation. Higher homeostasis model assessment of insulin resistance (HOMA-IR) was independently associated with newly developed atrial fibrillation (hazard ratio 1.61, 95% confidence interval 1.14-2.28). Atrial fibrillation development increased at the HOMA-IR levels approximately between 1-2.5, and then plateaued afterwards (p = 0.031).
Conclusion: There is a significant relationship between insulin resistance and atrial fibrillation development independent of other known risk factors, including obesity in a nondiabetic Asian population.
- URI
- https://academic.oup.com/eurjpc/article/27/18/1934/6125511https://repository.hanyang.ac.kr/handle/20.500.11754/162679
- ISSN
- 2047-4873; 2047-4881
- DOI
- 10.1177/2047487320908706
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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