Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이용구 | - |
dc.date.accessioned | 2021-07-06T05:35:56Z | - |
dc.date.available | 2021-07-06T05:35:56Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, v. 27, no. 18, page. 1934-1941 | en_US |
dc.identifier.issn | 2047-4873 | - |
dc.identifier.issn | 2047-4881 | - |
dc.identifier.uri | https://academic.oup.com/eurjpc/article/27/18/1934/6125511 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/162679 | - |
dc.description.abstract | Aims: Previous studies from Western countries have been unable to demonstrate a relationship between insulin resistance and new-onset atrial fibrillation. We aimed to evaluate this relationship in the nondiabetic Asian population. Methods: Between 2001-2003, 8175 adults (mean age 51.5 years, 53% women) without both existing atrial fibrillation and diabetes and with insulin resistance measures at baseline were enrolled and were followed by biennial electrocardiograms thereafter until 2014. We constructed multivariable-adjusted Cox proportional hazard models for risk of incident atrial fibrillation. Results: Over a median follow-up of 12.3 years, 136 participants (1.89/1000 person-years) developed atrial fibrillation. Higher homeostasis model assessment of insulin resistance (HOMA-IR) was independently associated with newly developed atrial fibrillation (hazard ratio 1.61, 95% confidence interval 1.14-2.28). Atrial fibrillation development increased at the HOMA-IR levels approximately between 1-2.5, and then plateaued afterwards (p = 0.031). Conclusion: There is a significant relationship between insulin resistance and atrial fibrillation development independent of other known risk factors, including obesity in a nondiabetic Asian population. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea grant funded by the Korean government (Ministry of Science (MSIT) (No. 2019R1F1A1046443)) and the research fund of Hanyang University (HY-2019). | en_US |
dc.language.iso | en | en_US |
dc.publisher | SAGE PUBLICATIONS LTD | en_US |
dc.subject | Insulin resistance | en_US |
dc.subject | atrial fibrillation | en_US |
dc.subject | obesity | en_US |
dc.subject | epidemiology | en_US |
dc.title | Association between insulin resistance and risk of atrial fibrillation in non-diabetics | en_US |
dc.type | Article | en_US |
dc.relation.no | 18 | - |
dc.relation.volume | 27 | - |
dc.identifier.doi | 10.1177/2047487320908706 | - |
dc.relation.page | 1934-1941 | - |
dc.relation.journal | EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY | - |
dc.contributor.googleauthor | Lee, Yonggu | - |
dc.contributor.googleauthor | Cha, Sung Joo | - |
dc.contributor.googleauthor | Park, Jung-Hwan | - |
dc.contributor.googleauthor | Shin, Jeong-Hun | - |
dc.contributor.googleauthor | Lim, Young-Hyo | - |
dc.contributor.googleauthor | Park, Hwan-Cheol | - |
dc.contributor.googleauthor | Shin, Jinho | - |
dc.contributor.googleauthor | Kim, Chun Ki | - |
dc.contributor.googleauthor | Park, Jin-Kyu | - |
dc.relation.code | 2020048473 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | hmedi97 | - |
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