Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김철근 | - |
dc.date.accessioned | 2021-05-18T05:49:08Z | - |
dc.date.available | 2021-05-18T05:49:08Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.citation | CANCER RESEARCH, v. 80, no. 11, page. 2217-2229 | en_US |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.issn | 1538-7445 | - |
dc.identifier.uri | https://cancerres.aacrjournals.org/content/80/11/2217 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/162273 | - |
dc.description.abstract | Stemness and epithelial-mesenchymal transition (EMT) are two fundamental characteristics of metastasis that are controlled by diverse regulatory factors, including transcription factors. Compared with other subtypes of breast cancer, basal-type or triple-negative breast cancer (TNBC) has high frequencies of tumor relapse. However, the role of alpha-globin transcription factor CP2 (TFCP2) has not been reported as an oncogenic driver in those breast cancers. Here, we show that TFCP2 is a potent factor essential for EMT, stemness, and metastasis in breast cancer. TFCP2 directly bound promoters of EGF and TGF alpha to regulate their expression and stimulate autocrine signaling via EGFR. These findings indicate that TFCP2 is a new antimetastatic target and reveal a novel regulatory mechanism in which a positive feedback loop comprising EGF/TGF alpha and AKT can control malignant breast cancer progression. Significance: TFCP2 is a new antimetastatic target that controls TNBC progression via a positive feedback loop between EGF/TGF alpha and the AKT signaling axis. | en_US |
dc.description.sponsorship | This study was supported by the Bio & Medical Technology Development Program of the National Research Foundation funded by the Korean government (MSIT; 2019M3E5D1A01069361 to S.-J. Lee). | en_US |
dc.language.iso | en | en_US |
dc.publisher | AMER ASSOC CANCER RESEARCH | en_US |
dc.subject | TRANSCRIPTION FACTOR LSF | en_US |
dc.subject | GROWTH-FACTOR RECEPTOR | en_US |
dc.subject | GENE-EXPRESSION | en_US |
dc.subject | STEM-CELLS | en_US |
dc.subject | TFCP2 | en_US |
dc.subject | RESISTANCE | en_US |
dc.subject | PROGNOSIS | en_US |
dc.subject | PROMOTER | en_US |
dc.subject | FAMILY | en_US |
dc.title | A Feedback loop comprising EGF/TGFα Sustains TFCP2-mediated Breast Cancer Progression | en_US |
dc.type | Article | en_US |
dc.relation.volume | 80 | - |
dc.identifier.doi | 10.1158/0008-5472.CAN-19-2908 | - |
dc.relation.page | 2217-2229 | - |
dc.relation.journal | CANCER RESEARCH | - |
dc.contributor.googleauthor | Zhao, Yi | - |
dc.contributor.googleauthor | Kaushik, Neha | - |
dc.contributor.googleauthor | Kang, Jae-Hyeok | - |
dc.contributor.googleauthor | Kaushik, Nagendra Kumar | - |
dc.contributor.googleauthor | Son, Seung Han | - |
dc.contributor.googleauthor | Uddin, Nizam | - |
dc.contributor.googleauthor | Kim, Min-Jung | - |
dc.contributor.googleauthor | Kim, Chul Geun | - |
dc.contributor.googleauthor | Lee, Su-Jae | - |
dc.relation.code | 2020054109 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | cgkim | - |
dc.identifier.orcid | http://orcid.org/0000-0002-5848-3338 | - |
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