Rifamycin O, An Alternative Anti-Mycobacterium abscessus Agent
- Title
- Rifamycin O, An Alternative Anti-Mycobacterium abscessus Agent
- Author
- 장기석
- Keywords
- rifamycin; Mycobacterium abscessus; zebrafish bacterial infection; drug resistance; non-tuberculous mycobacteria
- Issue Date
- 2020-03
- Publisher
- MDPI
- Citation
- MOLECULES, v. 25, no. 7, article no. 1597
- Abstract
- Mycobacterium abscessus is the most difficult-to-treat nontuberculous mycobacteria because of its resistance to many antibiotics. In this study, we screened the Korea Chemical Bank library for a bioluminescent reporter assay to identify molecules capable of acting against M. abscessus. On application of the assay, rifamycin O showed excellent in vitro activity with a narrow range of the minimum inhibitory concentration required to inhibit the growth of 90% of the bacterium (MIC90 = 4.0-6.2 mu M); its in vivo efficacy in the zebrafish (Danio rerio) infection model was comparable to that of rifabutin at 25 mu M. Furthermore, rifamycin O did not show significant toxicity in cells and the zebrafish model. These results are the first in vivo indication that rifamycin O may be a drug candidate for treating M. abscessus infections.
- URI
- https://www.mdpi.com/1420-3049/25/7/1597https://repository.hanyang.ac.kr/handle/20.500.11754/161964
- ISSN
- 1420-3049
- DOI
- 10.3390/molecules25071597
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
- Files in This Item:
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