Stereocomplex Formation between Enantiomeric PLA-PEG-PLA Triblock Copolymers: Characterization and Use as Protein Delivery Microparticulate Carriers
- Title
- Stereocomplex Formation between Enantiomeric PLA-PEG-PLA Triblock Copolymers: Characterization and Use as Protein Delivery Microparticulate Carriers
- Author
- 임동우
- Keywords
- Dilactide; 2-Hydroxybutyric Acid; Wide-Angle X-Ray Scattering
- Issue Date
- 2000-03
- Publisher
- JOHN WILEY & SONS INC
- Citation
- Journal of Applied Polymer Science, v. 75, issue. 13, page. 1615-1623
- Abstract
- Two enantiomeric triblock ABA copolymers composed of poly(L-lactide)-poly(ethylene glycol)-poly(L-lactide) (PLLA-PEG-PLLA) and poly(D-lactide)-poly(ethylene glycol)-poly(D-lactide) (PDLA-PEG-PDLA) were synthesized with two different middle-block PEG chain lengths by ring-opening polymerization of L-lactide and D-lactide in the presence of PEG, respectively. A pair of enantiomeric triblock copolymers were combined to form a stereocomplex by a solvent-casting method. The triblock copolymers and their stereocomplexes were characterized by H-1- and C-13-NMR spectroscopy and gel permeation chromatography. Their crystalline structures and crystalline melting behaviors were analyzed by the wide-angle X-ray diffraction method and differential scanning calorimetry. The stereocomplex formed between a pair of enantiomeric triblock copolymers exhibited a higher crystalline melting temperature with a distinctive 3/1 helical crystalline structure. PLLA-PEG-PLLA and its stereocomplex with PDLA-PEG-PDLA were used to fabricate a series of microspheres encapsulating a model protein drug, bovine serum albumin (BSA). They were prepared by a double-emulsion solvent-evaporation method. The morphological aspects of the microspheres were characterized and BSA release profiles from them were investigated.
- URI
- https://onlinelibrary.wiley.com/doi/10.1002/(SICI)1097-4628(20000328)75:13%3C1615::AID-APP7%3E3.0.CO;2-Lhttps://repository.hanyang.ac.kr/handle/20.500.11754/161812
- ISSN
- 0021-8995
- DOI
- 10.1002/(SICI)1097-4628(20000328)75:13<1615::AID-APP7>3.0.CO;2-L
- Appears in Collections:
- COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > BIONANO ENGINEERING(생명나노공학과) > Articles
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