Small-molecule-mediated reprogramming: a silver lining for regenerative medicine
- Title
- Small-molecule-mediated reprogramming: a silver lining for regenerative medicine
- Author
- 김요한
- Keywords
- PLURIPOTENT STEM-CELLS; HEPATIC PROGENITOR CELLS; BROWN ADIPOSE-TISSUE; MOUSE FIBROBLASTS; IN-VITRO; FUNCTIONAL CARDIOMYOCYTES; CARDIAC FIBROBLASTS; DIRECT CONVERSION; SOMATIC-CELLS; IPS CELLS
- Issue Date
- 2020-02
- Publisher
- Korean Society for Biochemistry and Molecular Biology
- Citation
- Experimental & molecular medicine, v. 52, no. 2, page. 213-226
- Abstract
- Techniques for reprogramming somatic cells create new opportunities for drug screening, disease modeling, artificial organ development, and cell therapy. The development of reprogramming techniques has grown exponentially since the discovery of induced pluripotent stem cells (iPSCs) by the transduction of four factors (OCT3/4, SOX2, c-MYC, and KLF4) in mouse embryonic fibroblasts. Initial studies on iPSCs led to direct-conversion techniques using transcription factors expressed mainly in target cells. However, reprogramming transcription factors with a virus risks integrating viral DNA and can be complicated by oncogenes. To address these problems, many researchers are developing reprogramming methods that use clinically applicable small molecules and growth factors. This review summarizes research trends in reprogramming cells using small molecules and growth factors, including their modes of action.
- URI
- https://www.nature.com/articles/s12276-020-0383-3https://repository.hanyang.ac.kr/handle/20.500.11754/161549
- ISSN
- 1226-3613; 2092-6413
- DOI
- 10.1038/s12276-020-0383-3
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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